{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:36:42Z","timestamp":1761745002385,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is no study to compare different class of antihypertensive drugs on new\u2010onset diabetes mellitus (NOD) in elderly. We aimed to investigate the risk of antihypertensive drugs on NOD in elderly patients. The databases were retrieved in an orderly manner from the dates of their establishment to October, 2018, including Medline, Embase, Clinical Trials, and the Cochrane Database, to collect randomized controlled trials (RCTs) of different antihypertensive drugs in elderly patients (age\u00a0&gt;\u00a060\u00a0years). Then, a network meta\u2010analysis was conducted using R and Stata 12.0 softwares. A total of 14 RCTs involving 74\u00a0042 patients were included. The relative risk of NOD mellitus associated with six classes of antihypertensive drugs was analyzed, including placebo, angiotensin\u2010converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), diuretics, and \u03b2 blockers. Patients with ACEIs or ARBs appeared to have significantly reduced risk of NOD compare with placebo: ACEIs (OR\u00a0=\u00a00.49, 95% CrI 0.28\u20100.85), ARBs (OR\u00a0=\u00a00.37, 95% CrI 0.26\u20100.52), while CCBs, diuretics, and \u03b2 blockers appeared to have not significantly reduced risk of NOD mellitus compare with placebo: CCBs (OR\u00a0=\u00a01.10, 95% CrI 0.85\u20101.60), diuretics (OR\u00a0=\u00a01.40, 95% CrI 0.92\u20102.50), \u03b2 blockers (OR\u00a0=\u00a01.40, 95% CrI 0.93\u20102.10). The SUCRA of placebo, ACEIs, ARBs, CCBs, diuretics, and \u03b2 blockers was, respectively, 65.3%, 69.3%, 92.3%, 44.1%, 12.1%, and 16.5%. According to the evidence, ARBs have an advantage over the other treatments in reducing the risk of NOD in elderly patients.<\/jats:p>","DOI":"10.1111\/jch.13598","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T13:09:08Z","timestamp":1561554548000},"page":"1082-1090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative risk of new\u2010onset diabetes mellitus for antihypertensive drugs in elderly: A Bayesian network meta\u2010analysis"],"prefix":"10.1111","volume":"21","author":[{"given":"Jinhua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Linyi Central Hospital Linyi City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aihua","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Linyi Central Hospital Linyi City 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