{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:06Z","timestamp":1790630526301,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationships between orthostatic hypotension (OH) and some kinds of cardiovascular disease are inconsistent among studies. This updated meta\u2010analysis was conducted in hopes of producing progress on this topic. A systematic database search was performed in electronic databases, including the Chinese Biomedical Database (CBM), PubMed, Web of Science, and the Cochrane Library. Summary hazard ratio (HR) estimates with 95% confidence intervals (CIs) were calculated by a random\u2010effects model. Statistical heterogeneity was assessed with Cochran's <jats:italic>Q<\/jats:italic> test and the <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistic. From 1462 potentially eligible records, 15 studies met the inclusion criteria. Subjects with OH had a high risk of heart failure (HF) and atrial fibrillation (AF) (pooled HR 1.34, 95% CI 1.17\u20101.52, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and pooled HR 1.51, 95% CI 1.28\u20101.79, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, respectively). This meta\u2010analysis also showed significant associations between OH and the risks of developing coronary heart disease (CHD) (pooled HR 1.44, 95% CI 1.18\u20101.75, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and myocardial infarction (MI) (pooled HR 1.52, 95% CI 1.12\u20102.06, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Our study suggests that OH is positively associated with high risks of HF and AF. Moreover, it may be related to high risks of CHD and MI.<\/jats:p>","DOI":"10.1111\/jch.13613","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T09:50:42Z","timestamp":1562752242000},"page":"1221-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Orthostatic hypotension and the risk of atrial fibrillation and other cardiovascular diseases: An updated meta\u2010analysis of prospective cohort studies"],"prefix":"10.1111","volume":"21","author":[{"given":"Min","family":"Min","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University Hefei 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