{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:54:16Z","timestamp":1783130056911,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T00:00:00Z","timestamp":1566604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307114\/2017\u20101"],"award-info":[{"award-number":["307114\/2017\u20101"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["203.007\/2015"],"award-info":[{"award-number":["203.007\/2015"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies aiming to associate the sodium\/potassium (Na\/K) ratio with hypertension use 24\u2010hour urinary excretion as a daily marker of ingestion. The objective of this study was to evaluate the association between urinary Na\/K ratio and structural and functional vascular alterations in non\u2010diabetic hypertensive patients. In hypertensive patients (n\u00a0=\u00a072), aged between 40 and 70\u00a0years, both sexes (61% women), in use of hydrochlorothiazide, we measured blood pressure, 24\u2010hour urine sample collection, assessment of carotid\u2010femoral pulse wave velocity (cf\u2010PWV, Complior), central hemodynamic parameters (SphygmoCor), and post\u2010occlusive reactive hyperemia (PORH). The participants were divided according to the tertile of 24\u2010hour urinary Na\/K ratio. Each group contained 24 patients. Systolic blood pressure was higher in T2 (133\u00a0\u00b1\u00a09 vs 140\u00a0\u00b1\u00a09\u00a0mmHg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.029). C\u2010reactive protein (CRP) presented higher values in T3 as compared to T1 [0.20(0.10\u20100.34) vs 1.19 (0.96\u20101.42) mg\/dL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001]. Higher values in T3 were also observed for aortic systolic pressure (aoSP) [119(114\u2010130) vs 135(125\u2010147) mmHg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002] and cf\u2010PWV (9.2\u00a0\u00b1\u00a01.6 vs 11.1\u00a0\u00b1\u00a01.5\u00a0m\/s, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The urinary Na\/K ratio presented significant correlations with proteinuria (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.27, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.023), CRP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.77, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), cf\u2010PWV (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.41, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and post\u2010occlusive reactive hyperemia on cutaneous vascular conductance (PORH CVC) (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.23, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.047). By multivariate linear regression, it was detected an independent and significant association of cf\u2010PWV with urinary Na\/K ratio (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.17, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and PORH CVC with CRP (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.30, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010). Our data indicated that increased urinary Na\/K ratio in non\u2010diabetic hypertensive patients was associated with higher degree of inflammation, raised peripheral and central pressure levels, and changes suggestive of endothelial dysfunction and arterial stiffness.<\/jats:p>","DOI":"10.1111\/jch.13660","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T08:08:32Z","timestamp":1566634112000},"page":"1360-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of urinary sodium\/potassium ratio with structural and functional vascular changes in non\u2010diabetic hypertensive patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-018X","authenticated-orcid":false,"given":"Michelle R.","family":"Cunha","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine State University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7377-1648","authenticated-orcid":false,"given":"Ana R.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine State University of Rio de Janeiro Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca C. 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