{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:03Z","timestamp":1772160663289,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600206"],"award-info":[{"award-number":["81600206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870195"],"award-info":[{"award-number":["81870195"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030310140"],"award-info":[{"award-number":["2016A030310140"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["20160903"],"award-info":[{"award-number":["20160903"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This was a post hoc analysis of Systolic Blood Pressure Intervention Trial (SPRINT), aimed to investigate whether intensive blood pressure treatment has differential therapeutic outcomes on patients with different baseline Framingham risk score (FRS). The 9298 SPRINT participants were categorized into low\u2010risk (baseline FRS\u00a0&lt;\u00a010%), intermediate\u2010risk (FRS\u00a0=\u00a010%\u201020%), or high\u2010risk (FRS\u00a0&gt;\u00a020%) arms. The primary outcome was a composite of myocardial infarction, acute coronary syndrome not resulting in myocardial infarction, stroke, acute decompensated heart failure, or death from cardiovascular causes. Serious adverse events were defined as hypotension, syncope, and bradycardia. Multiple Cox regression was used to calculate hazard ratios for study outcomes with intensive compared with standard SBP treatment between these three groups. After a median follow\u2010up time of 3.26\u00a0years, the primary outcome hazard ratio (HR) for intensive versus standard treatment was 0.73 (95% CI: 0.61\u20100.88,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.0044) in the high\u2010risk arm. And, for all\u2010cause mortality, the hazard ratio with intensive SBP treatment was 1.58 (95% CI: 0.55\u20101.06), 0.9 (95% CI: 0.26\u20109.50), and 0.53 (95% CI: 0.34\u20100.82) in three arms (all\n                    <jats:italic>P<\/jats:italic>\n                    values for interaction\u00a0&gt;\u00a00.05). Effects of intensive versus standard SBP control on serious adverse events were similar among patients with different FRS. Our results suggested that regardless of the FRS level, the intensive blood pressure control was beneficial.\n                  <\/jats:p>","DOI":"10.1111\/jch.13720","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T10:59:39Z","timestamp":1572519579000},"page":"1813-1820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effectiveness of blood pressure\u2013lowering treatment by the levels of baseline Framingham risk score: A post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT)"],"prefix":"10.1111","volume":"21","author":[{"given":"Ling","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Geriatrics the First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuting","family":"Sun","sequence":"additional","affiliation":[{"name":"Cardiology Department the First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"},{"name":"NHC Key Laboratory of Assisted Circulation Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhen","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangzhou Higher Education Mega Center Guangdong Pharmaceutical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaozhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cardiology Department the First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"},{"name":"NHC Key Laboratory of Assisted Circulation Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cardiology Department the First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"},{"name":"NHC Key Laboratory of Assisted Circulation Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Cardiology Department the First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"},{"name":"NHC Key Laboratory of Assisted Circulation Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-8507","authenticated-orcid":false,"given":"Xiaodong","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Cardiology Department the First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou China"},{"name":"NHC Key Laboratory of Assisted Circulation Sun Yat\u2010Sen University Guangzhou China"},{"name":"Center for Information Technology &amp; Statistics the First Affiliated Hospital Sun Yat\u2010Sen University Guangzhou 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