{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:21:48Z","timestamp":1747185708726,"version":"3.40.5"},"reference-count":69,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mozambique has low levels of detection, treatment, and control of hypertension. However, data on target organ damage and clinical outcomes are lacking. The authors aimed at characterizing the clinical profile, pattern of target organ damage, and short\u2010term outcomes of patients referred to a first referral urban hospital in a low\u2010income setting in Africa. We conducted a prospective descriptive cohort study from February 2016 to May 2017 in Maputo, Mozambique. Adult patients with systolic and diastolic blood pressure \u2265180\u00a0mm\u00a0Hg and\/or \u2265110\u00a0mm\u00a0Hg, respectively, or any systolic blood pressure above 140\u00a0mm\u00a0Hg and\/or diastolic blood pressure above 90\u00a0mm\u00a0Hg in the presence of target organ damage (with or without antihypertensive treatment) were submitted to detailed physical examination, funduscopy, laboratory profile, electrocardiography, and echocardiography. Six months after the occurrence of complications (stroke, heart failure, and renal failure), hospital admission and death were assessed. Overall, 116 hypertensive patients were recruited (mean age 57.5\u00a0\u00b1\u00a012.8\u00a0years old; 111[95.7%] black; 81[70%] female) of which 79 had severe hypertension. The baseline mean values recorded for systolic and diastolic blood pressure were 192.3\u00a0\u00b1\u00a023.6 and 104.2\u00a0\u00b1\u00a015.2\u00a0mm\u00a0Hg, respectively. Most patients (93; 80.2%) were on antihypertensive treatment. Patients\u2019 risk profile revealed dyslipidemia, obesity, and diabetes in 59(54.1%), 48(42.5%), and 23(19.8%), respectively. Target organ damage was found in 111 patients. The commonest being left atrial enlargement 91(84.5%), left ventricular hypertrophy 57(50.4%), hypertensive retinopathy 30(26.3%), and chronic kidney disease 27(23.3%). Major events during 6\u2010month follow\u2010up were hospitalizations in 10.3% and death in 8.6% of the patients. Worsening of target organ damage occurred in 10 patients: four stroke, two heart failure, and four renal damage. Patients with severe hypertension and target organ damage were young with high\u2010risk profile, low hypertension control, and high occurrence of complications during short\u2010term follow\u2010up. Efforts to improve high blood pressure control are needed to reduce premature mortality in this highly endemic poor setting.<\/jats:p>","DOI":"10.1111\/jch.13732","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T07:14:15Z","timestamp":1574752455000},"page":"1831-1840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypertension in a resource\u2010limited setting: Poor Outcomes on Short\u2010term Follow\u2010up in an Urban Hospital in Maputo, Mozambique"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-7673","authenticated-orcid":false,"given":"Naisa","family":"Manafe","sequence":"first","affiliation":[{"name":"Instituto Nacional de Saude Maputo Mozambique"},{"name":"Department of Medicine and Cardiology Faculty of Health Sciences University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ros\u00e1lia Nhabete","family":"Matimbe","sequence":"additional","affiliation":[{"name":"Hospital Geral de Mavalane Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefa","family":"Daniel","sequence":"additional","affiliation":[{"name":"Hospital Geral de Mavalane Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Lecour","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiology Faculty of Health Sciences University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Sliwa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cardiology Faculty of Health Sciences University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Olga","family":"Mocumbi","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Saude Maputo Mozambique"},{"name":"Universidade Eduardo Mondlane Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61766-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31919-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206776843368"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000056"},{"issue":"11","key":"e_1_2_9_6_1","first-page":"799","article-title":"Spectrum of hypertensive target organ damage in Africa: a review of Published Studies","volume":"8","author":"Mensah GA","year":"1994","journal-title":"J Hum Hypertens"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"46","article-title":"Racial differences in the impact of elevated systolic blood pressure on stroke risk. 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