{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:34:10Z","timestamp":1763346850646,"version":"3.40.5"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension is an important public health concern. The prevalence keeps increasing, and it is a risk factor for several adverse health outcomes including a decline in cognitive function. Recent data also show that the prevalence of hypertension and age\u2010related dementia is rising in Asian countries, including in the oldest old group. This study aims to discuss possible treatments for high blood pressure in the elderly and propose an optimal target for BP relative to cognitive outcomes. This review discusses several studies on related blood pressure treatments that remain controversial and the consequences if the treatment target is too low or aggressive. Longitudinal, cross\u2010sectional, and RCT studies were included in this review. An optimum systolic blood pressure of 120\u2010130\u00a0mm\u00a0Hg is recommended, especially in nondiabetic hypertensive patients with significant risk factors. In the oldest old group of patients, hypertension might have a protective effect. The use of calcium channel blockers (CCB) and angiotensin receptor blocker (ARB) is independently associated with a decreased risk of dementia in older people. However, personalized care for patients with hypertension, especially for patients who are frail or very old, is encouraged.<\/jats:p>","DOI":"10.1111\/jch.13752","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T16:08:56Z","timestamp":1575907736000},"page":"415-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High blood pressure in dementia: How low can we go?"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4527-0285","authenticated-orcid":false,"given":"Yuda","family":"Turana","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-1872","authenticated-orcid":false,"given":"Jeslyn","family":"Tengkawan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Atma Jaya Catholic University of Indonesia Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-0359","authenticated-orcid":false,"given":"Yook\u2010Chin","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences School of Healthcare and Medical Sciences Sunway University Bandar Sunway Malaysia"},{"name":"Department of Primary Care Medicine Faculty of Medicine University of Malaya Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-8507","authenticated-orcid":false,"given":"Boon Wee","family":"Teo","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore City Singapore"},{"name":"Division of Nephrology Department of Medicine National University Health System Singapore City Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-6504","authenticated-orcid":false,"given":"Jinho","family":"Shin","sequence":"additional","affiliation":[{"name":"Faculty of Cardiology Service Hanyang University Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guru Prasad","family":"Sogunuru","sequence":"additional","affiliation":[{"name":"MIOT International Hospital Chennai India"},{"name":"College of Medical Sciences Kathmandu University Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arieska Ann","family":"Soenarta","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine Faculty of Medicine University of Indonesia\u2010National Cardiovascular Center Harapan Kita Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huynh Van","family":"Minh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hue University Hospital Hue University Hue City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4710-2413","authenticated-orcid":false,"given":"Peera","family":"Buranakitjaroen","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Nailes","sequence":"additional","affiliation":[{"name":"University of the East Ramon Magsaysay Memorial Medical Center Inc. 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