{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:35:59Z","timestamp":1765546559759,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"TEIJIN PHARMA., Ltd."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A direct comparison of the effects of febuxostat and allopurinol on flow\u2010mediated dilatation (FMD) will help to clarify which agent provides a better reduction of cardiovascular risk in hypertensive patients. Hypertensive patients with hyperuricemia were randomized into a febuxostat (10\u201040\u00a0mg, n\u00a0=\u00a033) or allopurinol (100\u2010200\u00a0mg, n\u00a0=\u00a031) group and followed up for 6\u00a0months. Both the febuxostat (7.9\u00a0\u00b1\u00a01.3\u00a0mg\/dL vs 5.6\u00a0\u00b1\u00a01.0\u00a0mg\/dL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and allopurinol (8.2\u00a0\u00b1\u00a01.3\u00a0mg\/dL vs 6.1\u00a0\u00b1\u00a01.0\u00a0mg\/dL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) groups exhibited significant reductions in uric acid after treatment. There was no significant difference in the change in FMD between the two treatment groups (0.6\u00a0\u00b1\u00a02.6% vs 0.2\u00a0\u00b1\u00a02.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.504). However, stratified analysis showed that febuxostat achieved a significantly greater change in FMD compared to allopurinol in the elderly group (1.3\u00a0\u00b1\u00a02.9% vs \u22120.7%\u00b11.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.047). There was no difference in the improvement of FMD between febuxostat and allopurinol, but febuxostat may provide an improvement of FMD in elderly people.<\/jats:p>","DOI":"10.1111\/jch.13757","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T15:53:53Z","timestamp":1577202833000},"page":"451-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Class effect of xanthine oxidase inhibitors on flow\u2010mediated dilatation in hypertensive patients: A randomized controlled trial"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-5751","authenticated-orcid":false,"given":"Satoshi","family":"Hoshide","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Jichi Medical University School of Medicine Tochigi 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