{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:25:27Z","timestamp":1788279927550,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MOCHIDA PHARMACEUTICAL\u00a0Co., Ltd","award":["."],"award-info":[{"award-number":["."]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The home blood pressure (BP) control by a single\u2010pill combination of cilnidipine (an L\u2010\/N\u2010type calcium channel blocker; CCB) and valsartan (HOPE\u2010Combi) survey is a multicenter, post\u2010marketing, prospective observational study of a single\u2010pill combination of cilnidipine 10\u00a0mg and valsartan 80\u00a0mg (SPC of Cil\/Val) in patients with uncontrolled hypertension. We examined the effects of the SPC of Cil\/Val on morning home systolic BP (MHSBP) and morning home pulse pressure (MHPP) of 1036 patients with hypertension over 12\u00a0months. MHSBP decreased by 14.0\u00a0mm Hg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), and MHPP decreased by 6.6\u00a0mm Hg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Moreover, morning home pulse rate (MHPR) decreased by 2.1\u00a0bpm (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). A more progressive and greater decrease in MHSBP (\u221217.2 vs \u221210.3\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and MHPP (\u22127.6 vs \u22124.9\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) was observed in patients with higher MHPR (\u226570\u00a0bpm) than in those with lower MHPR (&lt;70\u00a0bpm) over the treatment period. In particular, in patients with a wide MHPP (\u226570\u00a0mm Hg), the difference in the MHPP reduction was greater in patients with higher MHPR than in those with lower MHPR (\u221217.9 vs \u221213.6\u00a0mm Hg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). These results suggested that the SPC of Cil\/Val, which possesses the unique sympatholytic characteristics of an L\u2010\/N\u2010type CCB, was particularly effective in patients with uncontrolled hypertension and sympathetic hyperactivity.<\/jats:p>","DOI":"10.1111\/jch.13771","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T18:56:14Z","timestamp":1587408974000},"page":"457-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Single\u2010pill combination of cilnidipine, an L\u2010\/N\u2010type calcium channel blocker, and valsartan effectively reduces home pulse pressure in patients with uncontrolled hypertension and sympathetic hyperactivity: The HOPE\u2010Combi survey"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Medical Research Group Medical Department EA Pharma Co., Ltd. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Nagahama","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Medical Research Group Medical Department EA Pharma Co., Ltd. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Kurose","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Medical Research Group Medical Department EA Pharma Co., Ltd. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Sugii","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Surveillance MOCHIDA PHARMACEUTICAL Co., Ltd. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Teshima","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Surveillance MOCHIDA PHARMACEUTICAL Co., Ltd. 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