{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:44:39Z","timestamp":1782485079965,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the availability of a numerous antihypertensive agents, hypertension treatment and control rates remain low in many countries. The role of the sympathetic nervous system has long been recognized, but recent sham control renal denervation studies demonstrated conflicting results. In this reviewe paper, the authors performed a systematic review and meta\u2010analysis to examine outcomes of sham\u2010controlled studies utilizing new technologies and procedures. Six published randomized, sham\u2010controlled studies were included in this meta\u2010analysis. Of those, three trials used the first\u2010generation radiofrequency renal denervation device and technique and the other three used second\u2010generation devices and techniques. In total, 981 patients with hypertension were randomized in all 6 trials to undergo renal denervation (n\u00a0=\u00a0585) or sham procedure (n\u00a0=\u00a0396). Overall, renal denervation resulted in a decrease of 24\u2010hours systolic ambulatory blood pressure (ABP) by 3.62\u00a0mm\u00a0Hg (95% CI: \u22125.28\u2010\u22121.96; I<jats:sup>2<\/jats:sup>\u00a0=\u00a00%), compared to sham procedure (GRADE: low). Renal denervation also reduced daytime systolic ABP by 5.51\u00a0mm\u00a0Hg (95% CI: \u22127.79\u2010\u22123.23; I<jats:sup>2<\/jats:sup>\u00a0=\u00a00%), compared to sham procedure but not nighttime systolic ABP. Office systolic blood pressure was reduced by 5.47\u00a0mm\u00a0Hg (95% CI \u22128.10\u2010\u22122.84; I<jats:sup>2<\/jats:sup>\u00a0=\u00a00%), compared to sham control. Further analysis demonstrated that second\u2010generation devices were effective in reducing blood pressure, whereas the first\u2010generation devices were not. These results indicate that effective renal denervation can result in significant and clinically meaningful blood pressure reduction. The second\u2010generation devices provide better renal nerve ablation.<\/jats:p>","DOI":"10.1111\/jch.13827","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T15:00:09Z","timestamp":1581519609000},"page":"572-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Efficacy and safety of renal denervation for the management of arterial hypertension: A systematic review and meta\u2010analysis of randomized, sham\u2010controlled, catheter\u2010based trials"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5549-7048","authenticated-orcid":false,"given":"Konstantinos","family":"Stavropoulos","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center Georgetown University District of Columbia Washington"},{"name":"2nd Propedeutic Department of Internal Medicine Aristotle University Thessaloniki 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