{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T06:22:34Z","timestamp":1770531754301,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shionogi & Co., Ltd."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Salt sensitivity is one of the crucial risk factors of hypertension. The aim of the present prospective cohort study was to assess the clinical impact of alcohol drinking on an association between salt intake and blood pressure. The present study included 451 employees at a pharmaceutical company in Japan who underwent annual health checkups in both 2017 and 2018. The main exposure of interest was self\u2010reported drinking frequency at their first checkups: rarely, occasionally, and daily. To assess the association between the change of salt intake estimated from single\u2010spot urine specimens and that of blood pressure, the differences in systolic\/diastolic blood pressure and salt intake between 2017 and 2018 were calculated for each subject. Multivariable\u2010adjusted linear regression models adjusting for clinically relevant factors clarified a drinking frequency\u2010dependent association between \u0394salt intake and \u0394systolic blood pressure (per 1\u00a0g\/d of \u0394salt intake adjusted <jats:italic>\u03b2<\/jats:italic> [95% confidence interval] 0.19 [\u22120.73, 1.12], 0.84 [0.14, 1.53], and 1.78 [0.86, 2.69] in rare, occasional, and daily drinkers). A similar association between \u0394salt intake and \u0394diastolic blood pressure was also observed (\u22120.24 [\u22121.02, 0.54], 0.67 (0.18, 1.16), 0.95 [0.38, 1.51], in rare, occasional, and daily drinkers). The interactions between drinking frequency and \u0394salt intake were found to be statistically significant (<jats:italic>P<\/jats:italic> for interaction\u00a0=\u00a0.028 and .006 for \u2206systolic blood pressure and \u2206diastolic blood pressure, respectively). The present study identified enhanced salt sensitivity in the subjects who drink at a higher frequency, suggesting that the reduction in alcohol consumption may improve salt sensitivity in higher frequency drinkers.<\/jats:p>","DOI":"10.1111\/jch.13844","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T11:53:25Z","timestamp":1584359605000},"page":"649-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Drinking frequency modifies an association between salt intake and blood pressure: A cohort study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9433-2249","authenticated-orcid":false,"given":"Ryuichi","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Department of Nephrology Osaka University Graduate School of Medicine Suita Japan"},{"name":"Division of Nephrology Shimane University Hospital Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-9824","authenticated-orcid":false,"given":"Ryohei","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology Osaka University Graduate School of Medicine Suita Japan"},{"name":"Health and Counseling Center Osaka University Toyonaka Japan"},{"name":"Heatlth Promotion and Regulation Department of Health Promotion Medicine Osaka University Graduate School of Medicine Toyonaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Shinzawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Tomi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Nephrology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Nephrology Shimane University Hospital Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV Shimane University Faculty of Medicine Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Moriguchi","sequence":"additional","affiliation":[{"name":"Shionogi Health Insurance Association Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Isaka","sequence":"additional","affiliation":[{"name":"Department of Nephrology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Nephrology Osaka University Graduate School of Medicine Suita Japan"},{"name":"Health and Counseling Center Osaka University Toyonaka Japan"},{"name":"Heatlth Promotion and Regulation Department of Health Promotion Medicine Osaka University Graduate School of Medicine Toyonaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000047"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.8.6_Pt_2.II127"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.521"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3281139ebd"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.429"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05189-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32225-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018526"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0122-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283524949"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-016-1315-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2017.57"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328316bb87"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-12-200112180-00005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws266"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-014-0513-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641960902825487"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02564"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.4.869"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.104968"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001307"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2282011860"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327110384520"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i5.245"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2014.987392"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.185"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-017-0007-z"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14392"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2014.11.010"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjch.13844","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.13844","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.13844","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.13844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:01:56Z","timestamp":1694041316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.13844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/jch.13844"],"URL":"https:\/\/doi.org\/10.1111\/jch.13844","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]},"assertion":[{"value":"2020-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}