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A recent shift from the definition of malignant hypertension to hypertension\u2010multiorgan damage (MOD) contributes to the diagnosis and management of hypertensive crises. Here, we prospectively included 166 adult (\u226518\u00a0years old) patients with hypertensive crises (blood pressure &gt;180\/120\u00a0mm\u00a0Hg). Target organs and causes of hypertension were assessed. Patients who were diagnosed with malignant hypertensive retinopathy, the absence of malignant hypertensive retinopathy but the presence of damage to at least 3 organs, and the absence of both retinopathy and MOD were classified as the malignant hypertension (n\u00a0=\u00a048), hypertension\u2010MOD (n\u00a0=\u00a042), and hypertension without MOD (n\u00a0=\u00a076) groups, respectively. Patients were followed to evaluate renal and cardiovascular prognoses. At baseline, patients with malignant hypertension had worse renal function, higher level of albuminuria, and more severe microvascular damage than those with hypertension\u2010MOD. Both had similar proportions of malignant arteriolar nephrosclerosis (83% vs 64%), left ventricular hypertrophy (90% vs 88%), abnormal repolarization (71% vs 60%), and left ventricular dysfunction (12% vs 21%). At the twenty months of follow\u2010up, both the malignant hypertension and hypertension\u2010MOD groups had similar blood pressure control rates and proteinuria. Both groups had worse renal outcomes than the hypertension without MOD group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). Patients with hypertension\u2010MOD (HR\u00a0=\u00a00.67, [95% CI: 0.30\u20101.46], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.31) had similar renal event\u2010free survival than patients with MHT after adjustments of age, sex, blood pressure, and proteinuria control. These results suggest that in hypertensive crises, both malignant hypertension and hypertension\u2010MOD have impact on adverse renal outcomes.<\/jats:p>","DOI":"10.1111\/jch.13848","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T17:26:48Z","timestamp":1586453208000},"page":"914-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical value of multiorgan damage in hypertensive crises: A prospective follow\u2010up study"],"prefix":"10.1111","volume":"22","author":[{"given":"Hongkun","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Nephrology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 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