{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:59:46Z","timestamp":1782485986328,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Single risk factors, such as hypertension and dyslipidemia, can combine to exacerbate the development and severity of cardiovascular disease. Treatment goals may be more effectively achieved if multiple disease factors are targeted with combination treatment. We enrolled 202 patients who were randomly divided into the following three groups: telmisartan\/amlodipine 80\/5\u00a0mg\u00a0+\u00a0rosuvastatin 20\u00a0mg, telmisartan 80\u00a0mg\u00a0+\u00a0rosuvastatin 20\u00a0mg, and telmisartan\/amlodipine 80\/5\u00a0mg. The primary efficacy variables were changes from baseline in mean sitting systolic blood pressure (MSSBP) between telmisartan\/amlodipine 80\/5\u00a0mg\u00a0+\u00a0rosuvastatin 20\u00a0mg and telmisartan 80\u00a0mg\u00a0+\u00a0rosuvastatin 20\u00a0mg at 8\u00a0weeks, and the percent changes from baseline in low\u2010density lipoprotein (LDL) cholesterol between telmisartan\/amlodipine 80\/5\u00a0mg\u00a0+\u00a0rosuvastatin 20\u00a0mg and telmisartan\/amlodipine 80\/5\u00a0mg at 8\u00a0weeks. The secondary efficacy variables were changes in MSSBP, mean sitting diastolic blood pressure (MSDBP), LDL cholesterol and other lipid levels at 4\u00a0weeks and 8\u00a0weeks, as well as observed adverse events during follow\u2010up. There were no significant differences between the three groups in demographic characteristics and no significant difference among the three groups in terms of baseline characteristics for the validity evaluation variables. The mean overall treatment compliance in the three groups was, respectively, 98.42%, 96.68%, and 98.12%, indicating strong compliance for all patients. The Least\u2010Square (LS) mean (SE) for changes in MSSBP in the two (telmisartan\/amlodipine 80\/5\u00a0mg\u00a0+\u00a0rosuvastatin 20\u00a0mg and telmisartan 80\u00a0mg\u00a0+\u00a0rosuvastatin 20\u00a0mg) groups were \u221219.3 (2.68) mm\u00a0Hg and \u22126.69 (2.76) mm\u00a0Hg. The difference between the two groups was significant (\u221212.60 (2.77) mm\u00a0Hg, 95% CI \u221218.06 to \u22127.14, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). The LS Mean for the percent changes from baseline in LDL cholesterol in the two (telmisartan\/amlodipine 80\/5\u00a0mg\u00a0+\u00a0rosuvastatin 20\u00a0mg and telmisartan\/amlodipine 80\/5\u00a0mg) groups were \u221252.45 (3.23) % and 2.68 (3.15) %. The difference between the two groups was significant (\u221255.13 (3.20) %, 95% CI \u221261.45 to \u221248.81, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). There were no adverse events leading to discontinuation or death. Combined administration of telmisartan\/amlodipine 80\/5\u00a0mg and rosuvastatin 20\u00a0mg for the treatment of hypertensive patients with dyslipidemia significantly reduces blood pressure and improves lipid control. ClinicalTrials.gov identifier: NCT03067688.<\/jats:p>","DOI":"10.1111\/jch.13893","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T22:40:33Z","timestamp":1600296033000},"page":"1835-1845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of co\u2010administered telmisartan\/amlodipine and rosuvastatin in subjects with hypertension and dyslipidemia"],"prefix":"10.1111","volume":"22","author":[{"given":"Xuan","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiology Dong\u2010A University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dong\u2010A University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki 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