{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:05:28Z","timestamp":1788379528514,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004697","name":"Hamadan University of Medical Sciences","doi-asserted-by":"publisher","award":["9510075751"],"award-info":[{"award-number":["9510075751"]}],"id":[{"id":"10.13039\/501100004697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Findings from randomized trials addressing the effect of vitamin D supplementation and blood pressure are inconsistent and have been the subject of recent debate. This study aimed to assess the effect of vitamin D supplementation on primary hypertension. This double\u2010blind randomized clinical trial was conducted on patients aged 26<jats:bold>\u2010<\/jats:bold>84 years with essential hypertension from March 2017 to April 2019. Patients with vitamin D insufficiency (serum vitamin D levels 20\u201030 ng\/ml) or vitamin D deficiency (serum vitamin D levels &lt;20 ng\/ml) were enrolled in the study. Patients were randomly assigned to receive vitamin D supplementation or placebo. Systolic and diastolic blood pressure was measured before the intervention and one and two months thereafter. Of 208 patients enrolled, 171 patients remained for analysis. The effect of vitamin D supplementation on systolic blood pressure was statistically significant in the first and second months after the intervention (<jats:italic>P<\/jats:italic>=0.004 and <jats:italic>P<\/jats:italic>=0.024, respectively). The effect of vitamin D supplementation on diastolic blood pressure was statistically significant in the first month after the intervention (<jats:italic>P<\/jats:italic>=0.046), but not in the second month (<jats:italic>P<\/jats:italic>=0.885). No evidence of drug side effects was reported in the two groups. The results of this trial are suggestive of the potential benefits of vitamin D supplementation on blood pressure end points. Therefore, the use of vitamin D may be recommended as an adjuvant drug in the treatment of essential hypertension in patients with vitamin D deficiency because it is safe and well\u2010tolerated by the patients and can significantly reduce the systolic and diastolic blood pressure.<\/jats:p><jats:p><jats:bold>Trial registration:<\/jats:bold> Iranian Registry of Clinical Trials registration number: IRCT201703129014N151.<\/jats:p>","DOI":"10.1111\/jch.13926","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T20:09:42Z","timestamp":1600632582000},"page":"1867-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double\u2010blind randomized clinical trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Vida","family":"Sheikh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine School of Medicine Hamadan University of Medical Sciences  Hamadan Iran"},{"name":"Clinical Research Development Unit of Shahid Beheshti Hospital Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Mozaianimonfared","sequence":"additional","affiliation":[{"name":"Department of Cardiology School of Medicine Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Gharakhani","sequence":"additional","affiliation":[{"name":"Department of Cardiology School of Medicine Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-3006","authenticated-orcid":false,"given":"Jalal","family":"Poorolajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ph.D","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health Hamadan University of Medical Sciences  Hamadan Iran"},{"name":"Modeling of Noncommunicable Diseases Research Center Hamadan University of Medical Sciences  Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Dietary reference intakes calcium vitamin D","author":"Ross AC","year":"2011"},{"key":"e_1_2_9_3_1","unstructured":"National Institutes of Health.D.etary supplement fact sheet: vitaminD.2011 [up D. te D. 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