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We aimed to study the association between cardiovascular drugs in AF patients and incident CHF. The study population included all adults (n\u00a0=\u00a0120\u00a0756) aged \u226545\u00a0years diagnosed with AF in Sweden diagnosed for the period 1998\u20102006. Outcome was incident congestive heart failure (follow\u2010up 2007\u20102015) in AF patients. Associations between treatment with cardiovascular pharmacotherapies and CHF were evaluated using Cox regression to estimate hazard ratios (HRs) with 95% CIs, after adjustment for age, sociodemographic variables, and comorbidities. During a mean 5.3\u00a0years (SD 3.0) of follow\u2010up, there were 28\u00a0257 (23.4%) incident cases of CHF. Treatment with beta\u20101\u2010selective and non\u2010selective beta\u2010blockers and statins was associated with lower risks of incident CHF in men, HR, (95% CI); 0.90, (0.87\u20100.94); 0.90, (0.84\u20100.97), and 0.94, (0.90\u20100.99), respectively. Only beta\u20101\u2010selective beta\u2010blockers were protective in women 0.94 (0.91\u20100.98). Treatment with loop diuretics, potassium\u2010saving agents, ACE inhibitors, and angiotensin receptor blockers was associated with a higher risk of CHF. For men, treatment with heart\u2010active calcium channel blockers also led to a higher risk of CHF. In conclusion, we found that beta\u2010blockers, in particular, but also statins were associated with lower risk of incident CHF in patients with AF.<\/jats:p>","DOI":"10.1111\/jch.13931","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T15:02:39Z","timestamp":1594825359000},"page":"1396-1405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of cardiovascular drugs and risk of incident heart failure in patients with atrial fibrillation"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5169-2965","authenticated-orcid":false,"given":"Per","family":"W\u00e4ndell","sequence":"first","affiliation":[{"name":"Division of Family Medicine and Primary Care Department of Neurobiology, Care Science and Society Karolinska Institutet  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel C.","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Division of Family Medicine and Primary Care Department of Neurobiology, Care Science and Society Karolinska Institutet  Huddinge Sweden"},{"name":"Academic Primary Health Care Centre Stockholm Region  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Holzmann","sequence":"additional","affiliation":[{"name":"Functional Area of Emergency Medicine Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Internal Medicine Karolinska Institutet  Solna Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"Department of Family Medicine and Community Health Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai  New York NY USA"},{"name":"Department of Functional Pathology Center for Community\u2010based Healthcare Research and Education (CoHRE) School of Medicine Shimane University  Matsue Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"Department of Family Medicine and Community Health Department of Population Health Science and Policy Icahn School of Medicine at Mount Sinai  New York NY USA"},{"name":"Department of Functional Pathology Center for Community\u2010based Healthcare Research and Education (CoHRE) School of Medicine Shimane University  Matsue 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