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AASL has a major impact on cardiovascular function and various biologic pathways that regulate blood pressure\u2013related phenotypes, but whether it affects the clinical response to antihypertensive therapy is unknown. The hemodynamic adaptations observed among lowlanders acutely exposed to high altitude (HA) is distinct from those observed among HA dwellers. However, the phenotypic patterns of hypertension and the response to standard antihypertensive agents among adults chronically exposed to different AASL are poorly understood. The authors describe the protocol for the INTERVENCION trial, a randomized clinical trial designed to assess the effects of three first\u2010line antihypertensive monotherapies (a thiazide diuretic, an angiotensin receptor blocker, and a calcium channel blocker) on peripheral and central blood pressure, in\u2010office blood pressure, and ambulatory blood pressure hemodynamics of hypertensive patients living at different AASL (low altitude, intermediate altitude, and high altitude). The primary end point is the reduction in 24\u2010hour brachial systolic blood pressure. The INTERVENCION trial will provide the first clinical trial data regarding the influence of AASL on the response to antihypertensive monotherapy, as well as the hemodynamic characteristics of arterial hypertension at different AASL.<\/jats:p>","DOI":"10.1111\/jch.13932","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T19:55:50Z","timestamp":1600372550000},"page":"1757-1762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of altitude on hypertension phenotypes and responses to antihypertensive therapy: Review of the literature and design of the INTERVENCION trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Josefina","family":"Medina\u2010Lezama","sequence":"first","affiliation":[{"name":"PREVENCION Research Institute Santa Maria Catholic University School of Medicine Arequipa 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