{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:08:16Z","timestamp":1787015296782,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG029824"],"award-info":[{"award-number":["U01AG029824"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008018","name":"Victorian Cancer Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["334037"],"award-info":[{"award-number":["334037"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1127060"],"award-info":[{"award-number":["1127060"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The association of different antihypertensive regimens with blood pressure (BP) control is not well\u2010described among community\u2010dwelling older adults with low comorbidity. We examined antihypertensive use and BP control in 10\u00a0062 treated hypertensives from Australia and the United States (US) using baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Renin\u2010angiotensin system (RAS) drugs were the most prevalently used antihypertensive in both countries (Australia: 81.7% of all regimens; US: 62.9% of all regimens;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). Diuretics were the next most commonly used antihypertensive in both countries, but were more often included in regimens of US participants (48.9%, vs 33.3% of regimens in Australia;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). Among all antihypertensive classes and possible combinations, monotherapy with a RAS drug was the most common regimen in both countries, but with higher prevalence in Australian than US participants (35.9% vs 20.9%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.001). For both monotherapy and combination users, BP control rates across age, ethnicity, and sex were consistently lower in Australian than US participants. After adjustment for age, sex, ethnicity, and BMI, significantly lower BP control rates remained in Australian compared to US participants for the most commonly used classes and regimens (RAS blocker monotherapy: BP control\u00a0=\u00a045.5% vs 54.2%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.002; diuretic monotherapy: BP control\u00a0=\u00a045.2% vs 64.5%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.001; and RAS blocker\/diuretic combo: BP control\u00a0=\u00a050.2% vs 65.6%;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.001). Our findings highlight variation in antihypertensive use in older adults treated for hypertension, with implications for BP control. Differences in BP control that were observed may be influenced, in part, by reasons other than choice of specific regimens.\n                  <\/jats:p>","DOI":"10.1111\/jch.13934","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T11:02:44Z","timestamp":1594810964000},"page":"1406-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Antihypertensive medication use and blood pressure control among treated older adults"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0267-4888","authenticated-orcid":false,"given":"Michael E.","family":"Ernst","sequence":"first","affiliation":[{"name":"Department of Family Medicine Carver College of Medicine The University of Iowa Iowa City IA USA"},{"name":"Department of Pharmacy Practice and Science College of Pharmacy The University of Iowa Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enayet K.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University VIC Australia"},{"name":"School of Public Health Curtin University Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University VIC Australia"},{"name":"School of Public Health Curtin University Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Margolis","sequence":"additional","affiliation":[{"name":"HealthPartners Institute Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Beilin","sequence":"additional","affiliation":[{"name":"Medical School Royal Perth Hospital University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel P.","family":"Stocks","sequence":"additional","affiliation":[{"name":"Discipline of General Practice Adelaide Medical School University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Murray","sequence":"additional","affiliation":[{"name":"Berman Center for Outcomes and Clinical Research Hennepin Healthcare Research Institute and University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Lockery","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne G.","family":"Orchard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn L.","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"McNeil","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ASPREE Investigator 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