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The intent of this study was to identify potential correlates of exercise tolerance in people with two types of chronic liver disease (CLD)\u2010NAFLD and HCV. Measures included cardiac output, oxygen consumption and stroke volume, blood pressure, distance walked in 6\u00a0minutes, clinical laboratory tests, and medications influencing the autonomic nervous system, patient self\u2010reports of activity, fatigue, and health\u2010related quality of life (HRQL). A total of 67 patients completed the 6\u2010minute walk test [45.1% Female, Age 51.7\u00a0\u00b1\u00a08.0\u00a0years, Body Mass Index 32.8\u00a0\u00b1\u00a05.9, 60% HCV]. At baseline, 70% had either diastolic (DBP) or systolic blood pressure outside normal range. Performance and cardiorespiratory measures correlated strongly with one another, but not with activity. Patients with abnormal DBP reported significantly lower maximum activity (MAS; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.254, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.041, CI\u00a0=\u00a0\u22120.51 to \u22120.010; MAS 70.6 vs 82.5), significantly higher DBP post\u20106\u2010minute walk test (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.524, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001, CI\u00a0=\u00a00.287\u20100.762) and significantly lower overall HRQL items related to physical domains (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.273, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.029, CI\u00a0=\u00a0\u22120.518 to \u22120.029). Mental\u2010domain HRQL and depression measures did not correlate significantly with blood pressure. This study reports a significant correlation between both pre\u2010hypertensive and hypertensive DBP, poor physical\u2010domain self\u2010reports, HRQL, and performance in CLD patients.<\/jats:p>","DOI":"10.1111\/jch.13938","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T19:44:00Z","timestamp":1600371840000},"page":"1915-1923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abnormal cardiac and metabolic measures correlate significantly with lower performance and activity in overweight chronic liver disease"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-2835","authenticated-orcid":false,"given":"Jillian","family":"Price","sequence":"first","affiliation":[{"name":"Inova Health System Betty and Guy Beatty Center for Integrated Research Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carey","family":"Escheik","sequence":"additional","affiliation":[{"name":"Inova Health System Betty and Guy Beatty Center for Integrated Research Falls Church VA USA"},{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Center for Study of Chronic Illness and Disability George Mason University Fairfax VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Winter","sequence":"additional","affiliation":[{"name":"Inova Health System Betty and Guy Beatty Center for Integrated Research Falls Church VA USA"},{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Gerber","sequence":"additional","affiliation":[{"name":"Inova Health System Betty and Guy Beatty Center for Integrated Research Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zobair","family":"Younossi","sequence":"additional","affiliation":[{"name":"Inova Health System Betty and Guy Beatty Center for Integrated Research Falls Church VA USA"},{"name":"Department of Medicine Center for Liver Diseases Inova Fairfax Hospital Falls Church VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.162"},{"issue":"1","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S1665-2681(19)31828-9","article-title":"Is exercise an effective treatment for NASH? 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