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However, clinical reference for the adequate management of blood pressure (BP) to prevent renal injury has yet to be established. Thus, this study aimed to investigate whether optimal control and maintenance of BP at\u00a0&lt;\u00a0140\/90, &lt; 130\/80, or\u00a0&lt;\u00a0120\/70\u00a0mmHg could prevent hypertensive nephropathy in nondiabetic hypertensive patients. A single\u2010center observational study of 351 nondiabetic hypertensive patients was conducted in Taiwan. The average age of the participants was 64.0\u00a0years, and approximately 57.8% of the participants were men. Kidney function was assessed using estimated glomerular filtration rate (eGFR). The baseline eGFR was 83.8\u00a0\u00b1\u00a019.8\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>. All patients were followed up every 3\u00a0months and underwent office BP measurement and blood sampling. Renal events were defined as&gt;\u00a025% and&gt;\u00a050% decline in eGFR. During an average follow\u2010up period of 4.2\u00a0\u00b1\u00a02.3\u00a0years, a&gt;\u00a025% and&gt;\u00a050% decline in eGFR was noted in 49 and 11 patients, respectively. The Cox regression analysis revealed that a baseline BP\u00a0\u2265\u00a0140\/90\u00a0mmHg (hazard ratio [HR]: 1.965; 95% confidence interval [CI]: 1.099\u20133.514, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023) and\u00a0\u2265\u00a0130\/80\u00a0mmHg (HR: 2.799; 95% CI: 1.286\u20136.004, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) increased the risk of&gt;\u00a025% decline in eGFR. Moreover, a baseline BP\u00a0\u2265\u00a0140\/90\u00a0mmHg (HR: 8.120; 95% CI: 1.650\u201339.956, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010) and follow\u2010up BP\u00a0\u2265\u00a0140\/90\u00a0mmHg (HR: 6.402; 95% CI: 1.338\u201330.637, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.020) increased the risk of&gt;\u00a050% decline in eGFR. In conclusion, a stringent baseline BP\u00a0&lt;\u00a0130\/80\u00a0mmHg and a follow\u2010up BP\u00a0&lt;\u00a0140\/90\u00a0mmHg can be considered optimal cutoff values for clinical practice to prevent hypertensive nephropathy.<\/jats:p>","DOI":"10.1111\/jch.13956","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T01:34:25Z","timestamp":1596764065000},"page":"1425-1433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optimal blood pressure for the prevention of hypertensive nephropathy in nondiabetic hypertensive patients in Taiwan"],"prefix":"10.1111","volume":"22","author":[{"given":"Ting\u2010Wei","family":"Kao","sequence":"first","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4217-8734","authenticated-orcid":false,"given":"Chin\u2010Chou","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Institute of Pharmacology National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaw\u2010Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Institute of Pharmacology National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Healthcare and Service Center Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000035855.44620.DA"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170321162233"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200208000-00001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-12-75"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_2_8_7_1","first-page":"e13","article-title":"ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines","volume":"71","author":"Whelton PK","year":"2017","journal-title":"Hypertension"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2014.11.005"},{"key":"e_1_2_8_9_1","volume-title":"U.S. Renal Data System: USRDS 2009 Annual Data Report: Atlas of Chronic Kidney Disease and End\u2010stage Renal Disease in the United States","author":"National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases","year":"2009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601043340103"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000127045.14709.75"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.111"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000095249.99803.85"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007994"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910975"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.0197"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00805-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001286"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801317"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12657"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.0315"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020145"},{"key":"e_1_2_8_25_1","unstructured":"Centers for Disease Control and Prevention: Chronic Kidney Disease Surveillance System website.https:\/\/nccd.cdc.gov\/CKD. 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