{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:46:52Z","timestamp":1785466012039,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary aldosteronism (PA) is associated with resistant hypertension and cardiovascular events. There are some limitations of current medical and surgical therapies for PA. To determine the efficacy and safety of catheter\u2010based adrenal artery ablation for treatment of PA patients who refused both surgery and medical therapy, we performed this prospective cohort study. Thirty\u2010six PA patients without apparent aldosteronoma were treated by adrenal artery ablation. Primary outcome was postoperative blood pressure and defined daily dose (DDD) of antihypertensive medications after adrenal ablation. Secondary outcome was biochemical success. We assessed outcomes based on Primary Aldosteronism Surgical Outcome (PASO) criteria. Adrenal CT scan, biochemical evaluation, adrenal artery ablation and adrenal venous sampling (AVS) were underwent. After adrenal ablation, complete clinical success (normotension without antihypertensive medication) was achieved in 9\/36 (25.0%) patients and partial clinical success (reduction in blood pressure or less antihypertensive medication) in 13\/36 (36.1%) patients. Complete biochemical success (correction of hypokalemia and normalization of aldosterone\u2010to\u2010renin ratio) was achieved in 16\/36 (44.4%) patients. Office\u2010based and ambulatory blood pressures were reduced by 17\/7 and 11\/2\u00a0mmHg at 6\u00a0months after ablation, respectively. The plasma cortisol level in the ablation group decreased slightly, but no patient developed hypoadrenocorticism. Catheter\u2010based adrenal ablation appears to produce substantial and sustained blood pressure reduction and biochemical improvement, with only minor adverse events in PA patients without apparent aldosteronoma. This therapy could be an important supplement for current PA treatments.<\/jats:p>","DOI":"10.1111\/jch.13960","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T16:11:55Z","timestamp":1598544715000},"page":"1618-1626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Adrenal artery ablation for primary aldosteronism without apparent aldosteronoma: An efficacy and safety, proof\u2010of\u2010principle trial"],"prefix":"10.1111","volume":"22","author":[{"given":"Hexuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangning","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunmei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingsha","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Translational Research Key Laboratory for Diabetes Xinqiao Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhencheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Translational Research Key Laboratory for Diabetes Xinqiao Hospital Third Military Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1035-5588","authenticated-orcid":false,"given":"Zhiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Endocrinology Center for Hypertension and Metabolic Diseases Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Chongqing Endocrine Hypertension Collaborative Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4061"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12831"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.057"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2805"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30319-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10263"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30367-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11568"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01316"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.07.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190311130138"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283455ca5"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.2003"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10596"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2272011798"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016152277"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9507"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000329"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-016-1524-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02097"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30135-3"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2234"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4146"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13442"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-5-200909010-00007"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.095448"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.5842"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003200"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12916"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.13960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.13960","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.13960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T20:02:19Z","timestamp":1693944139000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.13960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/jch.13960"],"URL":"https:\/\/doi.org\/10.1111\/jch.13960","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]},"assertion":[{"value":"2020-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}