{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:45:19Z","timestamp":1772937919470,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1604184"],"award-info":[{"award-number":["U1604184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies describing renal denervation (RDN) from the intima of the renal artery for the treatment of resistant hypertension have reported variable efficacies, and RDN triggers renal intimal injury and atherosclerosis. This study aimed to evaluate the efficacy and safety of RDN from the adventitia of renal artery plus unilateral laparoscopic adrenalectomy to treat patients with resistant hypertension caused by unilateral aldosterone\u2010producing adenoma (APA). A total of 60 consecutive patients with resistant hypertension caused by unilateral APA were enrolled in this study. Patients were randomly assigned to undergo RDN from the adventitia of the renal artery plus adrenalectomy (RDN group, n\u00a0=\u00a030) or adrenalectomy alone (control group, n\u00a0=\u00a030) and were followed up for 12\u00a0months. The primary efficacy end point was the change in 24\u2010hours mean ambulatory systolic blood pressure (SBP) from baseline to 12\u00a0months. At the 12\u2010month follow\u2010up, the mean reduction of 24\u2010hours average SBP and office SBP in the RDN group was 20.7\u00a0\u00b1\u00a015.2 and 37.1\u00a0\u00b1\u00a026.0\u00a0mm\u00a0Hg, respectively, which was significantly higher than the mean reduction of 24\u2010hours average SBP (11.9\u00a0\u00b1\u00a011.1\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017) and the office SBP (25.9\u00a0\u00b1\u00a016.8\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.035) in the control group. Serum potassium levels returned to normal 12\u00a0months post\u2010procedure. Patients in the RDN group had higher proportion of cured clinical and biochemical outcomes than those in the control group (35.7% vs 17.9% in clinical outcome; 96.4% vs 89.3% in biochemical outcome, respectively). There were no procedural\u2010, device\u2010, or treatment\u2010related safety events during the 12\u2010month follow\u2010up period between the groups. In conclusion, RDN from the adventitia of the renal artery plus unilateral laparoscopic adrenalectomy is more effective than adrenalectomy alone for treating resistant hypertension caused by unilateral APA.<\/jats:p>","DOI":"10.1111\/jch.13963","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T06:19:55Z","timestamp":1597817995000},"page":"1606-1615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical outcomes of laparoscopic\u2010based renal denervation plus adrenalectomy vs adrenalectomy alone for treating resistant hypertension caused by unilateral aldosterone\u2010producing adenoma"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-1210","authenticated-orcid":false,"given":"Yahui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology Henan University People's Hospital Henan Provincial People's Hospital  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