{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:07:55Z","timestamp":1773274075389,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008899","name":"Waksman Foundation of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Angiotensin receptor blockers (ARBs) plus calcium channel blockers (CCBs) are a widely used combination therapy for hypertensive patients. In order to determine which combination was better as the next\u2010step therapy for standard\u2010dose combination of ARBs and CCBs, a combination with high\u2010dose CCBs or a triple combination with diuretics, the authors conducted a prospective, randomized, open\u2010label trial to determine which of the following combination is better as the next\u2010step treatment: a combination with high\u2010dose CCBs or a triple combination with diuretics. Hypertensive outpatients who did not achieve their target blood pressure (BP) with usual dosages of ARBs and amlodipine 5\u00a0mg were randomly assigned to treatment with irbesartan 100\u00a0mg\/amlodipine 10\u00a0mg (Group 1: n\u00a0=\u00a048) or indapamide 1\u00a0mg in addition to ARBs plus amlodipine 5\u00a0mg (Group 2: n\u00a0=\u00a046). The primary end point was changes in the systolic BP (SBP) and diastolic BP (DBP) after the 12\u2010week treatment period, while secondary end points were changes in BP after the 24\u2010week treatment period and laboratory values. At 12\u00a0weeks, the SBP\/DBP significantly decreased from 152.1\/83.4\u00a0mm\u00a0Hg to 131.5\/76.1\u00a0mm\u00a0Hg in Group 1 and 153.9\/82.1\u00a0mm\u00a0Hg to 132.7\/75.9\u00a0mm\u00a0Hg in Group 2. Although both groups produced a similar efficacy in reducing the SBP\/DBP (\u221219.2\/\u20109.2\u00a0mm\u00a0Hg in Group 1 and \u221221.6\/\u20108.8\u00a0mm\u00a0Hg in Group 2; SBP <jats:italic>P<\/jats:italic>\u00a0=\u00a0.378, DBP <jats:italic>P<\/jats:italic>\u00a0=\u00a0.825), high\u2010dose CCBs combined with ARBs controlled hypertension without elevation of serum uric acid. These results will provide new evidence for selecting optimal combination therapies for uncontrolled hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.13977","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T01:35:31Z","timestamp":1596764131000},"page":"1577-1584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of suitable antihypertensive therapies: Combination with high\u2010dose amlodipine\/irbesartan vs triple combination with amlodipine\/irbesartan\/indapamide (ASAHI\u2010AI study)"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5398-3667","authenticated-orcid":false,"given":"Naoki","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Division of Cardiology, Nephrology, Pulmonology and Neurology Department of Internal Medicine Asahikawa Medical University Asahikawa 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Municipal Ashibetsu Hospital Ashibetsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Nephrology, Pulmonology and Neurology Department of Internal Medicine Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Hasebe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Nephrology, Pulmonology and Neurology Department of Internal Medicine Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the ASAHI\u2010AI 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