{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:06Z","timestamp":1787015346293,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sodium\u2010glucose cotransporter 2 (SGLT2) inhibitors reduce the occurrence of cardiovascular and renal complications in patients with type 2 diabetes mellitus (T2DM) and represent guideline\u2010recommended therapy in this indication. However, precise mechanisms underlying the beneficial cardiovascular effects of SGLT2 inhibitors are not fully understood. This study investigated the effects of the SGLT2 inhibitor, luseogliflozin, on arterial properties and home blood pressure (BP) in patients with T2DM. This multicenter, single\u2010arm study enrolled adults with T2DM, glycosylated hemoglobin (HbA1c) 6.5%\u20108.9% in the previous 4\u00a0weeks, and an indication for new\/additional antidiabetic therapy. Luseogliflozin 2.5\u00a0mg\/d was given for 12\u00a0weeks. Primary outcome was change in cardio\u2010ankle vascular index (CAVI) from baseline to Week 4 and Week 12. Home and office BP, BP variability, and metabolic parameters were secondary endpoints. Forty\u2010seven patients (mean age 63.5\u00a0\u00b1\u00a010.7\u00a0years) treated with luseogliflozin were included in the full analysis set. CAVI did not change significantly from baseline (mean [95% confidence interval] 8.67 [8.37\u20108.97]) to Week 12 (8.64 [8.38\u20108.91];\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.750), but there were significant reductions from baseline in morning home BP, HbA1c, body weight, body mass index, and serum uric acid levels during luseogliflozin therapy. The reduction in morning home systolic BP was\u00a0\u2265\u00a05\u00a0mm\u00a0Hg and was independent of baseline BP and BP control status. In conclusion, there was no change in arterial stiffness (based on CAVI) during treatment with luseogliflozin, but changes in BP and metabolic parameters were consistent with the known beneficial effects of SGLT2 inhibitors in T2DM.\n                  <\/jats:p>","DOI":"10.1111\/jch.13988","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T01:09:00Z","timestamp":1598576940000},"page":"1585-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of luseogliflozin on arterial properties in patients with type 2 diabetes mellitus: The multicenter, exploratory LUSCAR study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Jichi Medical University School of Medicine Tochigi Japan"},{"name":"Washiya Hospital Tochigi 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