{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:51:58Z","timestamp":1767340318105,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["97\u201001\u201001\u201017710"],"award-info":[{"award-number":["97\u201001\u201001\u201017710"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Currently, the best treatment strategy for patients with a high\u2010normal blood pressure (prehypertension) is not known. The authors aimed to determine whether pharmacological reduction of systolic blood pressure (SBP) to a normal level (&lt;120\u00a0mm\u00a0Hg) would prevent cardiac morbidity and mortality in prehypertensive patients. In this secondary analysis, the authors obtained the data from SPRINT from the National Heart, Lung, and Blood Institute data repository center. Among 9361 patients enrolled in SPRINT, 289 high\u2010risk (ASCVD risk\u00a0=\u00a024.8%\u00a0\u00b1\u00a013.0 [10\u201065]) prehypertensive patients without previous cardiovascular disease and not receiving any antihypertensive medications were enrolled. One hundred and forty\u2010eight of them were assigned to standard treatment which consisted of clinical follow\u2010up till SBP goes above 140\u00a0mm\u00a0Hg and then staring medications to keep SBP &lt;140\u00a0mm\u00a0Hg. One hundred and forty\u2010one were assigned to the intensive treatment receiving pharmacological SBP reduction to &lt;120\u00a0mm\u00a0Hg upon enrollment. The primary composite outcome was myocardial infarction, and other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes. Throughout the 3.06\u00a0years of follow\u2010up, a primary outcome event was confirmed in three participants (0.74% per year) in the intensive\u2010treatment group and 8 (1.61% per year) in the standard\u2010treatment group (hazard ratio [HR], 0.19; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045). Rates of serious adverse events were not increased by intensive\u2010treatment (HR, 0.83; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.506). Based on this secondary post hoc analysis, intensive SBP reduction may probably be beneficial for primary prevention of cardiovascular morbidity and mortality in high\u2010risk prehypertensive patients. This finding needs to be evaluated in a larger trial designed specifically to answer this question.<\/jats:p>","DOI":"10.1111\/jch.13994","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T05:09:00Z","timestamp":1598591340000},"page":"1627-1634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacological treatment of high\u2010normal blood pressure (prehypertension) in high\u2010risk patients for primary prevention of cardiovascular events"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-2490","authenticated-orcid":false,"given":"Roham","family":"Borazjani","sequence":"first","affiliation":[{"name":"Students' Research Committee Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Kojuri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Abdi\u2010Ardekani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyman","family":"Izadpanah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooyan","family":"Dehghani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrab","family":"Sayadi","sequence":"additional","affiliation":[{"name":"Students' 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