{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:18Z","timestamp":1790630538901,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T00:00:00Z","timestamp":1597536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/13\/16\/30528"],"award-info":[{"award-number":["RG\/13\/16\/30528"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The mechanisms underlying the association between orthostatic hypotension (OH) and cardiovascular disease are unclear. We investigated whether OH is associated with circulating cardiovascular risk markers. This was a cross\u2010sectional analysis of 3857 older, community\u2010dwelling men. \u201cConsensus OH\u201d was defined as a sitting\u2010to\u2010standing decrease in systolic blood pressure \u226520\u00a0mm\u00a0Hg and\/or diastolic blood pressure \u226510\u00a0mm\u00a0Hg that occurred within three minutes of standing. Multiple generalized linear regression and logistic models were used to examine the association between cardiovascular risk markers and OH. Consensus OH was present in 20.2%, consisting of isolated systolic OH in 12.6%, isolated diastolic OH in 4.6%, and combined systolic and diastolic OH in 3.0%. Concentration of von Willebrand factor, a marker of endothelial dysfunction, was positively associated with isolated systolic OH (OR 1.35, 95% CI 1.05\u20101.73) and combined systolic and diastolic OH (OR 2.27, 95% CI 1.35\u20103.83); high circulating phosphate concentration, which may reflect vascular calcification, was associated with isolated diastolic OH (OR 1.53, 95% CI 1.04\u20102.25) and combined systolic and diastolic OH (OR 2.12, 95% CI 1.31\u20103.44), high\u2010sensitivity troponin T, a marker of myocardial injury, was positively associated with isolated diastolic OH (OR 1.69, 95% CI 1.07\u20102.65) and N\u2010terminal pro\u2010brain natriuretic peptide, a marker of cardiac stress, was positively associated with combined systolic and diastolic OH (OR 2.14, 95% CI 1.14\u20104.03). In conclusion, OH is associated with some cardiovascular risk markers implicated in endothelial dysfunction, vascular calcification, myocardial injury, and cardiac stress. Clinicians should consider assessing cardiovascular risk in patients with OH.<\/jats:p>","DOI":"10.1111\/jch.13996","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T11:09:09Z","timestamp":1597576149000},"page":"1892-1901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Associations of the systolic and diastolic components of orthostatic hypotension with markers of cardiovascular risk in older men: A cross\u2010sectional analysis from The British Regional Heart Study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5385-8524","authenticated-orcid":false,"given":"Artaza","family":"Gilani","sequence":"first","affiliation":[{"name":"Research Department of Primary Care &amp; Population Health Royal Free Campus University College London London 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