{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:01:02Z","timestamp":1783976462657,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension affects approximately one\u2010third of the US adults. This study investigated antihypertensive utilization patterns among hypertensive patients who were prescribed treatment, yet still experienced uncontrolled hypertension. Data from the Decision Resources Group Real World Evidence Data Repository US database (2015\u20102016) were used to construct a cohort of uncontrolled hypertension patients to observe antihypertensive utilization patterns. Results for 5059 patients, with an average age of 57.8 (SD\u00a0=\u00a013.7), who had, on average 2.4 agents prescribed. Approximately half (51.9%) were female, and most were White (86.8%). More than one\u2010third (N\u00a0=\u00a01877; 37.1%) of patients were diagnosed with diabetes mellitus (DM) or chronic kidney disease (CKD) that could independently contribute to increased cardiovascular complications. Overall, the most common treatments prescribed, as percent of agents and as percent of patients, respectively, were diuretics (24.9%; 59.6%), followed by angiotensin\u2010converting enzyme inhibitors (ACEIs) (23.8%; 56.9%), beta\u2010blockers (BBs) (18.7%; 44.8%), calcium channel blockers (CCBs) (15.4%; 36.8%), and angiotensin II receptor blockers (ARBs) (13.5%; 32.3%). Approximately one\u2010tenth (10.5%) of the prescriptions were written for fixed\u2010dose combination therapies. Among patients diagnosed with DM and CKD (N\u00a0=\u00a0200), the order of the most common agents was the same as the overall cohort. Only 5.6% of prescriptions written for these patients were fixed\u2010dose combination therapy. Based on clinical guidelines, which suggest using ACEIs, ARBs, or CCBs as first\u2010line therapy, and fixed\u2010dose combination therapy to increase adherence, this indicates over\u2010prescribing of BBs and under\u2010prescribing of fixed\u2010dose combination therapy. These findings illustrate the need to further investigate challenges faced by patients and providers in treatment decision\u2010making.<\/jats:p>","DOI":"10.1111\/jch.14041","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T20:19:32Z","timestamp":1600633172000},"page":"2084-2092","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antihypertensive agent utilization patterns among patients with uncontrolled hypertension in the United States"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8119-4251","authenticated-orcid":false,"given":"Chris","family":"LaVallee","sequence":"first","affiliation":[{"name":"Division of Health Outcomes and Pharmacy Practice College of Pharmacy University of Texas Austin Texas USA"},{"name":"Decision Resources Group Health Outcomes Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9907-7670","authenticated-orcid":false,"given":"Karen L.","family":"Rascati","sequence":"additional","affiliation":[{"name":"Division of Health Outcomes and Pharmacy Practice College of Pharmacy University of Texas Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-1187","authenticated-orcid":false,"given":"Tyler H.","family":"Gums","sequence":"additional","affiliation":[{"name":"Division of Health Outcomes and Pharmacy Practice College of Pharmacy University of Texas Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"29","article-title":"Heart disease and stroke statistics\u20132015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian D","year":"2015","journal-title":"Circulation"},{"key":"e_1_2_9_3_1","unstructured":"Health. 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