{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:38:39Z","timestamp":1757705919535,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6\u20102019\u20100170"],"award-info":[{"award-number":["6\u20102019\u20100170"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Resistant hypertension was defined according to the 2008 scientific statement as office blood pressure\u00a0\u2265\u00a0140\/90\u00a0mm Hg and the 2018 scientific statement as office blood pressure\u00a0\u2265\u00a0130\/80\u00a0mm Hg. We investigated the prognostic significance of lowered blood pressure threshold for defining resistant hypertension in the 2018 American Heart Association scientific statement compared with that in the 2008 scientific statement. The participants of this prospective cohort were enrolled from December 2013 to November 2018. Major adverse cardiovascular events (MACEs) were defined as a composite of cardiovascular death, non\u2010fatal myocardial infarction, non\u2010fatal stroke, and heart failure hospitalization. Renal event was defined as a\u00a0\u2265\u00a050% decline in estimated glomerular filtration rate or progression to end\u2010stage renal disease. A total of 206 patients among 2018 (10.2%) were diagnosed with resistant hypertension by the previous definition (\u2265140\/90\u00a0mm Hg), and 276 patients among 2011 (13.7%) were diagnosed with resistant hypertension by the updated definition (\u2265130\/80\u00a0mm Hg). During a median follow\u2010up of 4.5\u00a0years, 33 MACEs (3.7 per 1000 patient\u2010years) and 164 renal events (19.9 per 1000 patient\u2010years) occurred in the study population. Treatment\u2010resistant hypertension groups had a higher incidence rate of MACEs and renal events than the control groups. In multivariate Cox proportional hazards regression analysis, resistant hypertension by both definitions was significantly associated with increased risk of MACE and renal event. Both the previous and updated definitions of resistant hypertension were significant predictors of MACEs and renal events. This finding supports the adoption of the updated criteria for resistant hypertension in clinical practice.<\/jats:p>","DOI":"10.1111\/jch.14043","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T19:32:21Z","timestamp":1600630341000},"page":"2093-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and prognosis of the 2018 vs 2008 AHA definitions of apparent treatment\u2010resistant hypertension in high\u2010risk hypertension patients"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-658X","authenticated-orcid":false,"given":"Kyeong\u2010Hyeon","family":"Chun","sequence":"first","affiliation":[{"name":"Division of Cardiology Severance Cardiovascular Hospital and Integrative Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Severance Cardiovascular Hospital and Integrative Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaewon","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Cardiology Severance Cardiovascular Hospital and Integrative Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Hak","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Severance Cardiovascular Hospital and Integrative Research Center for Cerebrovascular and Cardiovascular Diseases Yonsei University College of Medicine Seoul 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Cardiovascular Diseases Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000084"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12191"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.170308"},{"issue":"1","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2337\/dc19-1534","article-title":"Prognostic importance of resistant hypertension in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study","volume":"43","author":"Cardoso CRL","year":"2020","journal-title":"Diabetes 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