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However, there is no clear superiority\u2013inferiority differentiation between angiotensin\u2010converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), beta\u2010blockers (BB), calcium channel blockers (CCB), and diuretics in reversing LVH in hypertensive patients. To provide further evidence for choosing the optimal antihypertensive drug for improving LVH, we performed a network meta\u2010analysis of randomized controlled trials (RCTs) based on the Cochrane library database, Embase, and Pubmed, and identified 49 studies involving 5402 patients that were eligible for inclusion. It was found that ARB could improve LVH in hypertensive patients more effectively than CCB (MD \u22124.07, 95%CI \u22128.03 to \u22120.24) and BB (MD \u22124.57, 95%CI \u22128.07 to \u22121.12). Matched comparison of renin\u2010angiotensin system inhibitors (RASi) showed that the effect of ACEI in reducing left ventricular mass index (LVMi) was not effective as that of ARB (MD \u22123.72, 95%CI \u22127.52 to \u22120.11). The surface under the cumulative ranking for each intervention indicated that the use of ARB was more effective among the different types of antihypertensive drugs (97%). This network meta\u2010analysis revealed that the use of ARB in antihypertensive therapy could achieve better efficacy in reversing LVH in hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.14047","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T11:38:23Z","timestamp":1605440303000},"page":"2175-2183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Comparative efficacy of different types of antihypertensive drugs in reversing left ventricular hypertrophy as determined with echocardiography in hypertensive patients: A network meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8216-2756","authenticated-orcid":false,"given":"Jian\u2010Shu","family":"Chen","sequence":"first","affiliation":[{"name":"Lanzhou University Second College of Clinical Medicine Lanzhou 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