{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:11:50Z","timestamp":1793250710536,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to investigate myocardial performance using pressure\u2010strain loops in hypertensive patients with and without type 2 diabetes mellitus (DM). This cross\u2010sectional study included 165 subjects (55 controls, 60 hypertensive patients without DM, and 50 hypertensive patients with DM) who underwent complete two\u2010dimensional echocardiographic examination (2DE) including two\u2010dimensional speckle\u2010tracking echocardiography. Pressure\u2010strain curve was used to determine global myocardial work index, constructive work, wasted work, and work efficiency in all study participants. Left ventricular (LV) longitudinal and circumferential strains gradually reduced from controls throughout hypertensive subjects to patients with DM and hypertension. Global myocardial work index gradually increased from controls, throughout hypertensive patients to subjects with hypertension and DM (1887\u00a0\u00b1\u00a0289 vs 2073\u00a0\u00b1\u00a0311 vs 2144\u00a0\u00b1\u00a0345\u00a0mm\u00a0Hg%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Constructive work increased in the same direction (2040\u00a0\u00b1\u00a0319 vs 2197\u00a0\u00b1\u00a0344 vs 2355\u00a0\u00b1\u00a0379\u00a0mm\u00a0Hg%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Work efficiency and wasted work did not differ between three observed groups. Glycosylated hemoglobin and systolic blood pressure were associated with global myocardial work and constructive work independently of age, body mass index, LV structural and functional parameters in all hypertensive participants. In conclusion, pressure\u2010strain curve showed that myocardial work was significantly affected by hypertension and diabetes. Diabetes demonstrated an additional negative effect on myocardial work in hypertensive patients.<\/jats:p>","DOI":"10.1111\/jch.14053","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T17:52:18Z","timestamp":1600883538000},"page":"2121-2127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Myocardial work in hypertensive patients with and without diabetes: An echocardiographic study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-5152","authenticated-orcid":false,"given":"Marijana","family":"Tadic","sequence":"first","affiliation":[{"name":"Department of Cardiology University Hospital \u201cDr. Dragisa Misovic \u2010 Dedinje\u201d  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Cuspidi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University Milano\u2010Bicocca  Milano Italy"},{"name":"Clinical Research Unit Istituto Auxologico Italiano IRCCS  Meda Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Pencic","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital \u201cDr. Dragisa Misovic \u2010 Dedinje\u201d  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Grassi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University Milano\u2010Bicocca  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Celic","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital \u201cDr. Dragisa Misovic \u2010 Dedinje\u201d  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.11.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S206747"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.09.027"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00215.2019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.10.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex191"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev078"},{"issue":"2","key":"e_1_2_7_10_1","first-page":"257","article-title":"Global myocardial work is superior to global longitudinal strain to predict significant coronary artery 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