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The first is polypill that combines multiple low\u2010dose medications for controlling only one CVD risk factor (such as high blood pressure or high serum cholesterol). These \u201csingle\u2010purpose\u201d polypills were mostly developed from original producers and have higher cost. The polypill that combines 3\u20104 pharmaceutical components, each with potential to reduce one major cardiovascular risk factors is \u201cmulti\u2010purpose\u201d or \u201ccardiovascular\u201d polypill. Using data from various clinical trials and from meta\u2010analysis, Wald and Law claimed that this \u201ccardiovascular\u201d polypill when administered to every individual older than 55\u00a0years could reduce the incidence of CVD by more than 80%. Several short and intermediate to long\u2010term studies with different cardiovascular polypills in phase II and III trials showed that they could provide better adherence, equivalent, or better risk factor control and quality of life among users as compared to usual care. One recently published randomized controlled clinical trial demonstrated the effectiveness and safety of a four\u2010component polypill for both primary and secondary CVD prevention with acceptable number needed to treat (NNT) to prevent one major cardiovascular event. Considering the slow achievement of CVD prevention in many poor\u2010 and middle\u2010income Asian countries and also the need to further improve compliance of antihypertensive and lipid lowering medications in many high\u2010income Asian countries, the concept of \u201ccardiovascular polypill\u201d could be very useful. With further support from ongoing polypill cardiovascular outcome trials, polypill could be the foundation of the population\u2010based strategies for CVD prevention.<\/jats:p>","DOI":"10.1111\/jch.14075","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T21:25:35Z","timestamp":1603315535000},"page":"545-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The feasibility of polypill for cardiovascular disease prevention in Asian Population"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7569-9563","authenticated-orcid":false,"given":"Apichard","family":"Sukonthasarn","sequence":"first","affiliation":[{"name":"1Cardiology Division Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai 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