{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:52:37Z","timestamp":1783702357863,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension (HT) is a prominent cardiovascular risk factor. Although there are various pharmacological treatment choices for this condition, many patients fail to adhere to them, making non\u2010pharmacological options attractive alternatives. Foot reflexology has been proven to decrease blood pressure (BP), but data are limited in patients with stage\u20102 HT. We conducted a randomized clinical trial to examine the effectiveness of foot reflexology in reducing BP and heart rate (HR). Stage\u20102 HT patients were enrolled and randomized into the intervention and the control groups (<jats:italic>n<\/jats:italic>\u00a0=\u00a047, each), the former of which underwent foot reflexology during a follow\u2010up visit. Office BP and HR were measured before and at 15 and 30\u00a0min after the procedure in the intervention group and after resting in the control group. In the intervention group, systolic BP (SBP), diastolic BP (DBP), and HR at 15\u00a0min were significantly lower than at baseline: \u22123.29\u00a0mm\u00a0Hg (95%CI; \u22125.64 to \u22120.93), \u22121.71\u00a0mm\u00a0Hg (95%CI; \u22123.11 to \u22120.32), and \u22121.71 beats per min (bpm; 95%CI; \u22122.88 to \u22120.54), respectively. Similar trends were also observed at 30\u00a0min. However, when compared with the control group, only the reduction in HR was significant (\u22124.96\u00a0bpm; 95%CI, \u22129.63 to \u22120.28). We conclude that foot reflexology was effective in reducing HR in stage\u20102 HT patients and partially effective in reducing BP.<\/jats:p>","DOI":"10.1111\/jch.14103","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T18:14:25Z","timestamp":1605464065000},"page":"680-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The effects of foot reflexology on blood pressure and heart rate: A randomized clinical trial in stage\u20102 hypertensive patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3519-3415","authenticated-orcid":false,"given":"Praew","family":"Kotruchin","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supap","family":"Imoun","sequence":"additional","affiliation":[{"name":"Accident and Emergency Nursing Unit Srinagarind Hospital Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thapanawong","family":"Mitsungnern","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patcharin","family":"Aountrai","sequence":"additional","affiliation":[{"name":"Accident and Emergency Nursing Unit Srinagarind Hospital Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneenuch","family":"Domthaisong","sequence":"additional","affiliation":[{"name":"Accident and Emergency Nursing Unit Srinagarind Hospital Faculty of Medicine Khon Kaen University Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Jichi Medical University School of Medicine Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.7.947"},{"key":"e_1_2_9_3_1","first-page":"1","article-title":"Hypertension among adults in the United States: National Health and Nutrition Examination Survey, 2011\u20132012","volume":"133","author":"Nwankwo T","year":"2013","journal-title":"NCHS Data 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