{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:02Z","timestamp":1787015342334,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["S1101022"],"award-info":[{"award-number":["S1101022"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Whether marked nocturnal blood pressure (BP) reduction is associated with cardiovascular disease (CVD) is still controversial. In addition, no report has yet discussed the relationship between lower nocturnal BP and CVD, involving modification by nighttime hypoxia. We evaluated 840 patients who had one or more cardiovascular risk factors by measuring their high\u2010sensitivity cardiac troponin T (Hs\u2010cTnT), N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010pro BNP), and nighttime saturation levels and performing ambulatory BP monitoring. The lowest tertile in nighttime diastolic BP (DBP) (\u226466\u00a0mmHg) had increased likelihood of the presence of \u22650.014\u00a0ng\/ml of Hs\u2010cTnT compared with the second tertile (odds ratio [OR] 1.91, 95% confidence interval [CI] 1.01\u20133.63), and the lowest tertile of minimum blood oxygen saturation (\u226481%) had increased likelihood of the presence of \u22650.014\u00a0ng\/ml of Hs\u2010cTnT compared with the third tertile (OR 2.15, 95% CI 1.13\u20134.10). Additionally, the patients with both lowest tertile of nighttime DBP and minimum SpO2 showed increased likelihood of the presence of \u22650.014\u00a0ng\/ml of Hs\u2010cTnT compared with those without this combination (OR 2.93, 95% CI 1.40\u20136.16). On the other hand, these associations were not found in the presence of \u2265125\u00a0pg\/ml of NT\u2010pro BNP. In the clinical population, each of lower nocturnal DBP and nighttime hypoxia was associated with asymptomatic myocardial injury, which was represented as higher Hs\u2010cTnT, and coexisting lower nocturnal DBP and nighttime hypoxia had an additive effect on the risk of myocardial injury.<\/jats:p>","DOI":"10.1111\/jch.14132","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T05:31:48Z","timestamp":1607923908000},"page":"272-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of lower nighttime diastolic blood pressure and hypoxia with silent myocardial injury: The Japan Morning Surge\u2010Home Blood Pressure study"],"prefix":"10.1111","volume":"23","author":[{"given":"Kana","family":"Kubota","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Jichi Medical University Tochigi 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