{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:59:36Z","timestamp":1772254776247,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T00:00:00Z","timestamp":1610841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We examined the effects of a fixed\u2010dose single\u2010pill combination of cilnidipine (10\u00a0mg), an L\u2010\/N\u2010type calcium channel blocker, and valsartan (80\u00a0mg) (SPC of Cil\/Val) on the day\u2010by\u2010day variability of morning home systolic blood pressure (MHSBP) in 616 patients with treated hypertension for 12\u00a0months as a sub\u2010analysis of the HOPE\u2010Combi survey, multicentral, post\u2010marketing, and prospective observational survey. The SPC of Cil\/Val was administrated once a day in the morning. The SPC of Cil\/Val decreased the standard deviation (SD, from 6.3\u00a0\u00b1\u00a04.8 to 5.1\u00a0\u00b1\u00a03.8\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), coefficient of variation (from 4.3\u00a0\u00b1\u00a03.2 to 3.8\u00a0\u00b1\u00a02.9%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), average real variability (ARV, from 7.9\u00a0\u00b1\u00a06.6 to 6.3\u00a0\u00b1\u00a05.1\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), and the difference between maximum and minimum (MMD, from 11.9\u00a0\u00b1\u00a09.2 to 9.7\u00a0\u00b1\u00a07.2\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) of MHSBP. The variability of MHSBP increased with age; however, this was not increased in patients \u226570\u00a0years at the baseline. In elderly patients (\u226570\u00a0years, <jats:italic>N<\/jats:italic>\u00a0=\u00a0283), the SPC of Cil\/Val decreased the SD (from 6.9\u00a0\u00b1\u00a05.6 to 5.6\u00a0\u00b1\u00a04.4\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), ARV (from 8.6\u00a0\u00b1\u00a07.7 to 6.9\u00a0\u00b1\u00a05.7\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), and MMD (from 13.2\u00a0\u00b1\u00a010.7 to 10.7\u00a0\u00b1\u00a08.3\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) of MHSBP at 12\u00a0months; the reduction in these MHSBP variability parameters was comparable to that in adults &lt;70\u00a0years. These results suggest that the SPC of Cil\/Val is effective in reducing day\u2010by\u2010day variability of MHSBP in elderly patients.<\/jats:p>","DOI":"10.1111\/jch.14178","type":"journal-article","created":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T18:38:36Z","timestamp":1610908716000},"page":"392-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Single\u2010pill combination of cilnidipine, an l\u2010\/n\u2010type calcium channel blocker, and valsartan reduces the day\u2010by\u2010day variability of morning home systolic blood pressure in patients with treated hypertension: A sub\u2010analysis of the HOPE\u2010combi survey"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Medical Research Group, Medical Department EA Pharma Co., Ltd. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Nagahama","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Medical Research Group, Medical Department EA Pharma Co., Ltd. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Kurose","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Medical Research Group, Medical Department EA Pharma Co., Ltd. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Sugii","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Surveillance Mochida Pharmaceutical Co., Ltd. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Teshima","sequence":"additional","affiliation":[{"name":"Post\u2010Marketing Surveillance Mochida Pharmaceutical Co., Ltd. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Mochida Pharmaceutical Co., Ltd. Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,17]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton 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