{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:26:43Z","timestamp":1791588403752,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our study aimed to explore the intercorrelations of brachial\u2010ankle pulse wave velocity (baPWV), ankle\u2010brachial index (ABI), ambulatory arterial stiffness index (AASI), 24\u2010hour mean pulse pressure (24\u2010h\u00a0\u00a0 PP), and augmentation index (AIx, AIx@75, the AIx standardized to a heart rate of 75) and compare the effectiveness of these markers for predicting renal outcomes. A total of 117 patients with chronic kidney disease (CKD) who received noninvasive arterial stiffness examinations were enrolled. We used correlation analysis and linear regression to explore the correlations between these five arterial stiffness markers and the Cox proportional hazards model and receiver operator characteristic (ROC) curve to assess the associations of markers with kidney disease outcomes. The median (interquartile range) of age and eGFR were 61 (49\u201065) years and 50.5 (35.5\u201084.1) ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, respectively. In Pearson correlation analysis, baPWV was significantly associated with 24\u2010h\u00a0 PP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.531, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), AIx@75 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.306, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Additionally, 24\u2010h\u00a0 PP was associated with AASI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.507, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and AIx@75 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.217, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.019). During follow\u2010up for a median of 25\u00a0months, 26.5% (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) of patients had a composite outcome; of these, 10 initiated dialysis, 17 had 40% eGFR loss, and 4 died. Increased AASI, 24\u2010h\u00a0 PP, and baPWV were associated with poor renal outcomes in a univariate Cox analysis. After adjusting for age, sex, MAP, eGFR, and 24\u00a0hours proteinuria, 1\u2010SD increase in AASI and 24\u2010h\u00a0 PP was associated with renal outcomes. The ROC analysis yielded the largest area under the curve (AUC) of 0.727 (95% CI: 0.624 to 0.831; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) for 24\u00a0 \u2010h PP. When the Youden's index was at its maximum, the 24\u2010h PP value was 52\u00a0mmHg. In conclusion, 24\u2010h\u00a0 PP, baPWV, and AIx@75 were linked well to one another. Arterial stiffness is a target for delaying the decline in kidney function. The use of 24\u2010h\u00a0 PP as an arterial stiffness marker should be valued in CKD clinical practice.<\/jats:p>","DOI":"10.1111\/jch.14185","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T17:10:44Z","timestamp":1612285844000},"page":"823-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Noninvasive markers of arterial stiffness and renal outcomes in patients with chronic kidney disease"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9454-2315","authenticated-orcid":false,"given":"Xinru","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Nephrology Medical School of Chinese PLA The First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisha","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Medical School 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Medical School of Chinese PLA The First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology Medical School of Chinese PLA The First Medical Center Chinese PLA General Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Nephrology Medical School of Chinese PLA The First Medical Center Chinese PLA General Hospital Beijing 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