{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:43:24Z","timestamp":1784875404481,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potential cancer risk associated with long\u2010term exposure to angiotensin receptor blockers (ARBs) is still unclear. We assessed the risk of incident cancer among hypertensive patients who were treated with ARBs compared with patients exposed to angiotensin\u2010converting enzyme inhibitors (ACEIs), which are known to have a neutral effect on cancer development. Using the Korean National Health Insurance Service database, we analyzed the data of patients diagnosed with essential hypertension from January 2005 to December 2012 who were aged \u226540\u00a0years, initially free of cancer, and were prescribed either ACEI or ARB (n\u00a0=\u00a0293,962). Cox proportional hazard model adjusted for covariates was used to evaluate the risk of incident cancer. During a mean follow\u2010up of 10\u00a0years, 24,610 incident cancers were observed. ARB use was associated with a decreased risk of overall cancer compared with ACEI use (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.72\u20100.80). Similar results were obtained for lung (HR 0.73, 95% CI 0.64\u20100.82), hepatic (HR 0.56, 95% CI 0.48\u20100.65), and gastric cancers (HR 0.74, 95% CI 0.66\u20100.83). Regardless of the subgroup, greater reduction of cancer risk was seen among patients treated with ARB than that among patients treated with ACEIs. Particularly, the decreased risk of cancer among ARB users was more prominent among males and heavy drinkers (interaction <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.005). Dose\u2010response analyses demonstrated a gradual decrease in risk with prolonged ARB therapy than that with ACEI use. In conclusion, ARB use was associated with a decreased risk of overall cancer and several site\u2010specific cancers.<\/jats:p>","DOI":"10.1111\/jch.14187","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T19:44:41Z","timestamp":1611603881000},"page":"879-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of angiotensin receptor blockers on the development of cancer: A nationwide cohort study in korea"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-5178","authenticated-orcid":false,"given":"Mi\u2010Hyang","family":"Jung","sequence":"first","affiliation":[{"name":"Cardiovascular Center Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Chungbuk National University College of Medicine Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Severance Cardiovascular Hospital and Cardiovascular Research Institute Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Hun","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Hanyang University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Hyuck","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hee","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Konkuk University Medical Center Konkuk University School of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo\u2010hyeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Hanyang University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6703-1472","authenticated-orcid":false,"given":"Hack Lyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Boramae Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyue Mee","family":"Kim","sequence":"additional","affiliation":[{"name":"Heart Research Institute ChungAng University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Jeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Ewha Womans University Medical Center Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iksung","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology Severance Cardiovascular Hospital and Cardiovascular Research Institute Yonsei University College of Medicine Seoul Republic of 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Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook\u2010Jin","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Gil Hospital Gachon University Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5017-5421","authenticated-orcid":false,"given":"Sang\u2010Hyun","family":"Ihm","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Bucheon St. Mary\u2019s Hospital The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of 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