{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:24:55Z","timestamp":1782487495299,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension is often associated with metabolic changes. The sustained increase in sympathetic activity is related to increased blood pressure and metabolic changes. Environmental stimuli may be related to increased sympathetic activity, blood pressure, and metabolic changes, especially in genetically predisposed individuals. The aim of this study was to evaluate the response of fatty acids to physical and mental stress in healthy volunteers and the hemodynamic, hormonal, and metabolic implications of these stimuli. Fifteen healthy individuals with a mean age of 31\u00a0\u00b1\u00a07\u00a0years, of both sexes, were evaluated. They were assessed at baseline and after combined physical and mental stress (isometric exercise test, Stroop color test). Blood samples were collected at baseline and after stimulation for glucose, insulin, fatty acid, and catecholamine levels. Blood pressure, heart rate, cardiac output, systemic vascular resistance, and distensibility of the large and small arteries were analyzed. The data obtained at baseline and after stimuli were from the same individual, being the control itself. Compared to baseline, after physical and mental stress there was a statistically significant increase (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in free fatty acids, norepinephrine, diastolic blood pressure, peripheral vascular resistance, and distensibility of the large and small arteries. In conclusion, the combination of physical and mental stress raised fatty acids, norepinephrine, diastolic blood pressure, and peripheral vascular resistance in healthy individuals.<\/jats:p>","DOI":"10.1111\/jch.14190","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T16:11:14Z","timestamp":1611936674000},"page":"888-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Acute physical and mental stress resulted in an increase in fatty acids, norepinephrine, and hemodynamic changes in normal individuals: A possible pathophysiological mechanism for hypertension\u2014Pilot study"],"prefix":"10.1111","volume":"23","author":[{"given":"Josiane","family":"Motta e Motta","sequence":"first","affiliation":[{"name":"Hospital Campo Limpo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila Neves","family":"Souza","sequence":"additional","affiliation":[{"name":"Hospital Campo Limpo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Bassetto","family":"Vieira","sequence":"additional","affiliation":[{"name":"Hospital Campo Limpo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Delle","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho\u2010UNINOVE Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Marciano","family":"Consolim\u2010Colombo","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho\u2010UNINOVE Sao Paulo Brazil"},{"name":"Heart Institute (InCor) Medical School Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent M.","family":"Egan","sequence":"additional","affiliation":[{"name":"University of South Carolina School of Medicine \u2013 Greenville Greenville SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9591-3093","authenticated-orcid":false,"given":"Heno Ferreira","family":"Lopes","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) Medical School Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2011.66"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.46.030184.001043"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2008.74"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.1.H245"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e3282cb05db"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727\u2010154\u201039630"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2013\/5094.3043"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u2010879X2008005000042"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/2.12.339S"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199705000-00004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(99)00074-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37246-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02166-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.6.1392"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.723"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279\u2010015\u20100394\u20108"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90613.2008"},{"key":"e_1_2_6_19_1","first-page":"589","article-title":"Serum free fatty acid level and body temperature changes in emotional stress in rabbits. 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