{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:45:45Z","timestamp":1792622745601,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypertension is the most considerable but treatable risk factor for cardiovascular disease. Although physicians prescribe multiple antihypertensive drugs and promote lifestyle modifications, the real\u2010world blood pressure (BP) control rate remains poor. To improve BP target achievement, we developed a novel digital therapeutic\u2014the HERB software system\u2009\u2014to manage hypertension. Here, we performed a randomized pilot study to assess the safety and efficacy of the HERB system for hypertension. We recruited 146 patients with essential hypertension from March 2018 to March 2019. We allocated eligible patients to the intervention group (HERB system\u00a0+\u00a0standard lifestyle modification) or control group (standard lifestyle modification alone). The primary outcome was the mean change from baseline to 24\u00a0weeks in 24\u2010hour systolic BP (SBP) measured by ambulatory blood pressure monitoring (ABPM). The baseline characteristics in each group were well balanced; the mean age was approx. 57\u00a0years, and 67% were male. In the primary end point at 24\u00a0weeks, HERB intervention did not lower the mean change of 24\u2010hour SBP by ABPM compared with the controls (adjusted difference: \u22120.66\u00a0mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.78). In an exploratory analysis focusing on antihypertensive drug\u2010na\u00efve patients aged &lt;65, the effects of the HERB intervention were significantly greater than the control for reducing 24\u2010hour SBP by ABPM at 16\u00a0weeks (adjusted difference: \u22127.6\u00a0mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.013; and morning home SBP at 24\u00a0weeks (adjusted difference\u00a0\u2212\u00a06.0\u00a0mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.012). Thus, the HERB intervention did not achieve a primary efficacy end point. However, we observed that antihypertensive drug\u2010na\u00efve adult hypertensive patients aged &lt;65\u00a0years could be a potential HERB system\u2010effective target for further investigations of the efficacy of the system.\n                  <\/jats:p>","DOI":"10.1111\/jch.14191","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T13:41:37Z","timestamp":1611409297000},"page":"923-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Digital therapeutics for essential hypertension using a smartphone application: A randomized, open\u2010label, multicenter pilot study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine School of Medicine Jichi Medical University Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-8240","authenticated-orcid":false,"given":"Akihiro","family":"Nomura","sequence":"additional","affiliation":[{"name":"CureApp Institute Karuizawa Japan"},{"name":"Innovative Clinical Research Center Kanazawa University Kanazawa Japan"},{"name":"Department of Cardiovascular Medicine Kanazawa University Graduate School of Medical Sciences Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6306-6600","authenticated-orcid":false,"given":"Ayaka","family":"Kato","sequence":"additional","affiliation":[{"name":"CureApp Institute Karuizawa Japan"},{"name":"CureApp, Inc. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine School of Medicine Jichi Medical University Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6799-3519","authenticated-orcid":false,"given":"Tomoyuki","family":"Tanigawa","sequence":"additional","affiliation":[{"name":"CureApp Institute Karuizawa Japan"},{"name":"CureApp, Inc. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-350X","authenticated-orcid":false,"given":"Ryuhei","family":"So","sequence":"additional","affiliation":[{"name":"CureApp Institute Karuizawa Japan"},{"name":"CureApp, Inc. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5358-9619","authenticated-orcid":false,"given":"Shin","family":"Suzuki","sequence":"additional","affiliation":[{"name":"CureApp, Inc. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9381-2013","authenticated-orcid":false,"given":"Eisuke","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1035-4481","authenticated-orcid":false,"given":"Kohta","family":"Satake","sequence":"additional","affiliation":[{"name":"CureApp Institute Karuizawa Japan"},{"name":"CureApp, Inc. Tokyo Japan"},{"name":"Department of Respiratory Medicine Japanese Red Cross Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.20"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0284-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11203"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032851"},{"issue":"17","key":"e_1_2_9_6_1","first-page":"e426","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"138","author":"Whelton PK","year":"2018","journal-title":"Circulation"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2196\/13520"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-020-0243-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13081055"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(20)30017-0"},{"key":"e_1_2_9_11_1","unstructured":"Digital Therapeutics Alliance.https:\/\/dtxalliance.org. 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