{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:10:20Z","timestamp":1791274220543,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Controversy exists about the association of choroidal thickness (CTh) with blood pressure (BP) values. There is some evidence suggesting that central hemodynamics changes are associated with microvascular disease. Our study was aimed to assess the relationships between CTh and clinic and 24\u2010h BP and between CTh and estimated 24\u2010h aortic pulse pressure (aPP), 24\u2010h aortic systolic BP (aSBP), and 24\u2010h aortic augmentation index (aAIx) in a group of hypertensive patients. We enrolled 158 hypertensive subjects (mean age 48\u00a0\u00b1\u00a013\u00a0years) all of which underwent evaluation of the choroidal district by Swept\u2010Source optical coherence tomography (SS\u2010OCT) and 24\u2010h BP monitoring, in order to measure peripheral BP and to estimate central hemodynamic parameters. Inverse significant correlations of clinic PP, 24\u2010h aPP, 24\u2010h aSBP, and 24\u2010h aAIx with thicknesses of central ring, inner ring, and outer ring of the choroid and its overall average were found. The strongest of these correlations was that relating 24\u2010h aPP with overall average choroidal thickness (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.531; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). When we divided the study population in subjects with 24\u2010h aPP above and below the median value (35\u00a0mm Hg), CTh were thinner in subjects with higher values of 24\u2010aPP as compared to those with lower ones, even after adjustment for age, and other potential confounders. The relationships of CTh with 24\u2010h aPP remained significant also taking into account the effects of various covariates in linear multiple regression analyses. Our findings support the concept of a cross\u2010talk between macro\u2010 and microcirculation.<\/jats:p>","DOI":"10.1111\/jch.14196","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T21:07:42Z","timestamp":1611608862000},"page":"1030-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship of choroidal thickness with pulsatile hemodynamics in essential hypertensive patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-8671","authenticated-orcid":false,"given":"Giuseppe","family":"Mul\u00e8","sequence":"first","affiliation":[{"name":"Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties \u201cG. D\u2019Alessandro\u201d (PROMISE) University of Palermo Palermo Italy"},{"name":"Unit of Nephrology and Hypertension European Society of Hypertension Excellence Centre Universit\u00e0 degli studi di Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vadal\u00e0","sequence":"additional","affiliation":[{"name":"Dipartimento di Biomedicina sperimentale e Neuroscienze cliniche Universit\u00e0 degli studi di Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Sinatra","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties \u201cG. D\u2019Alessandro\u201d (PROMISE) University of Palermo Palermo Italy"},{"name":"Unit of Nephrology and Hypertension European Society of Hypertension Excellence Centre Universit\u00e0 degli studi di Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Mancia","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties \u201cG. D\u2019Alessandro\u201d (PROMISE) University of Palermo Palermo Italy"},{"name":"Unit of Nephrology and Hypertension European Society of Hypertension Excellence Centre Universit\u00e0 degli studi di Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Sorce","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties \u201cG. D\u2019Alessandro\u201d (PROMISE) University of Palermo Palermo Italy"},{"name":"Unit of Nephrology and Hypertension European Society of Hypertension Excellence Centre Universit\u00e0 degli studi di Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3806-1151","authenticated-orcid":false,"given":"Giulio","family":"Geraci","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties \u201cG. D\u2019Alessandro\u201d (PROMISE) University of Palermo Palermo Italy"},{"name":"Unit of Nephrology and Hypertension European Society of Hypertension Excellence Centre Universit\u00e0 degli studi di Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Carollo","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties \u201cG. D\u2019Alessandro\u201d (PROMISE) University of Palermo Palermo Italy"},{"name":"Unit of Nephrology and Hypertension European Society of Hypertension Excellence Centre Universit\u00e0 degli studi di Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Montalbano","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences, Maternal and Infant Care Internal Medicine and Medical Specialties \u201cG. 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