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Between 1985 and 2017, 1,173 SRs were published, and in the last 20\u00a0years, 10, 35, and 116 were published in the year 1996, 2006, and 2016, respectively. Angiotensin\u2010converting enzyme inhibitors\/angiotensin II receptor blockers were the most common class of drugs studied. Fourteen percent of the SRs were prospectively registered\/published protocol. Three\u2010fourth of the SRs did not report a full search strategy, and 45% did not report a PRISMA or similar diagram. Of the 34 SRs published in the five high impact factor journals in the last 10\u00a0years, 15%, 21%, and 65% have unclear, low, and high risk of bias, respectively. There has been a steady increase in the publication of SRs of RCTs of AHTDs. However, adherence to standard methods of conduct and reporting continues to be low.<\/jats:p>","DOI":"10.1111\/jch.14216","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T13:47:54Z","timestamp":1614692874000},"page":"915-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Systematic reviews of antihypertensive drugs: A review of publication trends, characteristics, and quality"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5900-7694","authenticated-orcid":false,"given":"Hariprasad","family":"Esam","sequence":"first","affiliation":[{"name":"The George Institute for Global Health  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju","family":"Kanukula","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupasvi","family":"Dhurjati","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupa","family":"Aerram","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sindhujareddy","family":"Chevireddy","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumyadeep","family":"Bhaumik","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Atkins","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"},{"name":"Westmead Clinical School University of Sydney  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Huffman","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"},{"name":"Department of Preventive Medicine Northwestern University Feinberg School of Medicine  Chicago USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Rodgers","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Salam","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Hyderabad India"},{"name":"Prasanna School of Public Health  Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.11.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32225-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3163\/1536-5050.104.1.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196644"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117537"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058484"},{"key":"e_1_2_9_9_1","first-page":"486","article-title":"Epistemonikos: a free, relational, collaborative, multilingual database of health evidence","volume":"192","author":"Rada G","year":"2013","journal-title":"Stud Health Technol Inform"},{"key":"e_1_2_9_10_1","unstructured":"Epistemonikos.org.Epistemonikos: database of the best evidence\u2010based health care. 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