{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:23:01Z","timestamp":1747185781065,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91639203","82070435"],"award-info":[{"award-number":["91639203","82070435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dyslipidemia is an emerging disease in China, especially in the presence of hypertension and diabetes mellitus. We investigated the association of dyslipidemia with the use of antihypertensive and antidiabetic agents. The study participants (n\u00a0=\u00a02423) were hypertensive and diabetic patients enrolled in a China nationwide registry. Serum mean \u00b1 (SD, except for serum triglycerides, median [interquatile range]) concentrations were 1.38 (0.97\u20102.02) mmol\/L, 4.85\u00a0\u00b1\u00a01.12\u00a0mmol\/L, 1.30\u00a0\u00b1\u00a00.36\u00a0mmol\/L, and 2.89\u00a0\u00b1\u00a00.92\u00a0mmol\/L for triglycerides and total, high\u2010density lipoprotein (HDL), and low\u2010density lipoprotein (LDL) cholesterol, respectively. The prevalence of dyslipidemia was 18.9%, 13.5%, 16.6%, and 37.7% for hypertriglyceridemia (serum triglycerides \u22652.3\u00a0mmol\/L), hypercholesterolemia (total cholesterol \u22656.2\u00a0mmol\/L or LDL cholesterol \u22654.1\u00a0mmol\/L), low HDL cholesterol (HDL cholesterol &lt;1.0\u00a0mmol\/L), and any of the three lipid disorders, respectively. Treated (n\u00a0=\u00a01647), compared with untreated hypertensive patients (n\u00a0=\u00a0303), had a significantly (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.0006) lower serum total, LDL, and HDL cholesterol, but similar serum triglycerides (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.20). Treated (n\u00a0=\u00a01325), compared with untreated diabetic patients (n\u00a0=\u00a0238), had a significantly (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.004) lower serum triglycerides, and total and LDL cholesterol, but similar serum HDL cholesterol (<jats:italic>P<\/jats:italic> = .81). After adjustment, the odds ratios (OR) were significant for hypercholesterolemia (OR 0.76, 95% confidence interval [CI] 0.58\u20100.997, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048) and low HDL cholesterol (OR 1.56, CI 1.19\u20102.03, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) in treated versus untreated hypertension, and for low HDL cholesterol (OR 1.50, CI 1.18\u20101.89, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0008) in treated versus untreated diabetes. In conclusion, the prevalence of dyslipidemia differed between treated and untreated hypertension and diabetes.<\/jats:p>","DOI":"10.1111\/jch.14264","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T04:09:56Z","timestamp":1623038996000},"page":"1399-1404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between dyslipidemia and antihypertensive and antidiabetic treatments in a China multicenter study"],"prefix":"10.1111","volume":"23","author":[{"given":"Chao\u2010Ying","family":"Miao","sequence":"first","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Fei","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-1598","authenticated-orcid":false,"given":"Li\u2010Nong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Renmin Hospital Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-1524","authenticated-orcid":false,"given":"Ji\u2010Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Shanghai Institute of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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