{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:24:44Z","timestamp":1788546284780,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006680","name":"Takeda Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Faster pulse wave velocity (PWV) is known to be associated with the incidence of cardiovascular diseases (CVD). The aim of this study was to clarify the hypothesis that PWV may be associated with future CVD events even when its time\u2010dependent changes were adjusted. We also investigated a prognostic significance of cardio\u2010ankle vascular index, another index of arterial stiffness. Study participants included 8850 community residents. The repeated measures of the clinical parameters at 5.0\u00a0years after the baseline were available for 7249 of the participants. PWV was calculated using the arterial waveforms measured at the brachia and ankles (baPWV). The cardio\u2010ankle vascular index was calculated by estimated pulse transit time from aortic valve to tibial artery. During the 8.53\u00a0years follow\u2010up period, we observed 215 cases of CVD. The incidence rate increased linearly with baPWV quartiles (per 10\u00a0000 person\u2010years: Q1, 2.7; Q2, 12.6; Q3, 22.5; Q4, 76.2), and the highest quartile was identified as an independent determinant of incident CVD by conventional Cox proportional hazard analysis adjusted for known risk factors [hazard ratio (HR), 4.00; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007]. Per unit HR of baPWV (HR, 1.15; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) remained significant in the time\u2010dependent Cox regression analysis including baPWV and other clinical values measured at 5\u2010year after the baseline as time\u2010varying variables (HR, 1.14; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The cardio\u2010ankle vascular index was also associated with CVD with similar manner though the associations were less clear than that of baPWV. baPWV is a good risk marker for the incidence of CVD.<\/jats:p>","DOI":"10.1111\/jch.14294","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T04:43:35Z","timestamp":1622090615000},"page":"1390-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Brachial\u2010ankle pulse wave velocity and cardio\u2010ankle vascular index are associated with future cardiovascular events in a general population: The Nagahama Study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4505-7951","authenticated-orcid":false,"given":"Tabara","family":"Yasuharu","sequence":"first","affiliation":[{"name":"Center for Genomic Medicine Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Setoh","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Kyoto University Graduate School of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health  Shizuoka Japan"},{"name":"Department of Health Informatics Kyoto University School of Public Health  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine Kyoto University Graduate School of Medicine  Kyoto Japan"},{"name":"Graduate School of Public Health Shizuoka Graduate University of Public Health  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Nagahama study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000033"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010020\u20100420\u20106"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002081"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.359"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832e94e7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.07023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2013.103"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04063"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.103"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09097"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.328"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001672"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.7716"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.32797"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001602"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010019\u20100276\u20109"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.19356"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.6.611"},{"key":"e_1_2_8_20_1","unstructured":"WHO Monica Project.MONICA Manual. (1998\u20131999).http:\/\/www.ktl.fi\/publications\/monica\/manual\/index.htm URN:NBN:fi\u2010fe19981146. (Accessed on 29 October 2019)."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430771"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001838"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv127"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpv079"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpw036"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.04.018"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt080"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.01.032"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13659"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpw045"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13496"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.14294","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T05:31:03Z","timestamp":1697088663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/jch.14294"],"URL":"https:\/\/doi.org\/10.1111\/jch.14294","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,26]]},"assertion":[{"value":"2021-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}