{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:23:56Z","timestamp":1759040636392},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, the authors aimed to assess both nighttime and daytime blood pressure (BP) variability using 24\u2010hour ambulatory BP monitoring (ABPM) in persons with and without psychiatric conditions and with or without selective serotonin reuptake inhibitors (SSRIs) or serotonin\u2010norepinephrine reuptake inhibitors (SNRIs) treatment. In this retrospective study, patients who underwent psychiatric evaluation and ABPM within 6 months of each other between January 1, 2012 and December 31, 2017 were identified using billing data. Participants were divided into three groups\u2014participants with no psychiatric diagnosis and no psychiatric medicine (\u2212Diagnosis\/\u2212Medication), those with psychiatric diagnosis and on SSRIs\/SNRIs (+Diagnosis\/+Medication), and psychiatric diagnosis but no psychiatric medications (+Diagnosis\/\u2212Medication). Day and nighttime systolic and diastolic BPs were compared between groups controlling for relevant variables using multivariable linear regression models. A total of 475 participants met inclusion criteria including 135 in the \u2212Diagnosis\/\u2212Medication group, 232 in the +Diagnosis\/+Medication group, and 108 in the +Diagnosis\/\u2212Medication group. In adjusted multivariable analysis, the +Diagnosis\/+Medication group had higher nighttime systolic BP (median 120\u00a0vs 110\u00a0mm (Hg); <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01) and nighttime diastolic BP (median 68\u00a0vs 63\u00a0mm (Hg); <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006) as compared to \u2212Diagnosis\/\u2212Medication. No statistically significant differences in BPs between the \u2212Diagnosis\/\u2212Medication and +Diagnosis\/\u2212Medication groups were observed, after adjustment. Use of SSRIs\/SNRIs was associated with significantly higher nocturnal systolic and diastolic BP among patients with psychiatric diagnosis using SSRIs\/SNRIs but not associated with psychiatric diagnosis without SSRI\/SNRI use. SSRIs\/SNRIs use may be associated with higher BP levels and this merits future prospective studies using ABPM to assess day and nighttime BP changes with SSRIs\/SNRIs use.<\/jats:p>","DOI":"10.1111\/jch.14311","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T07:02:17Z","timestamp":1624950137000},"page":"1599-1607","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24\u2010hour ambulatory blood pressure monitoring"],"prefix":"10.1111","volume":"23","author":[{"given":"Shehzad K.","family":"Niazi","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Psychology Mayo Clinic Florida  Jacksonville Florida USA"},{"name":"Mayo Clinic Robert D. &amp; Patricia E. 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