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This study aimed to develop and validate a risk scoring system considering the effects of glycemic and blood pressure (BP) variabilities to predict HTN incidence in patients with type 2 diabetes. This research is a retrospective cohort study that included 3416 patients with type 2 diabetes without HTN and who were enrolled in a managed care program in 2001\u20132015. The patients were followed up until April 2016, new\u2010onset HTN event, or death. HTN was defined as diastolic BP (DBP) \u2265 90\u00a0mm Hg, systolic BP (SBP) \u2265 140\u00a0mm Hg, or the initiation of antihypertensive medication. Cox proportional hazard regression model was used to develop the risk scoring system for HTN. Of the patients, 1738 experienced new\u2010onset HTN during an average follow\u2010up period of 3.40 years. Age, sex, physical activity, body mass index, type of DM treatment, family history of HTN, baseline SBP and DBP, variabilities of fasting plasma glucose, SBP, and DBP and macroalbuminuria were significant variables for the prediction of new\u2010onset HTN. Using these predictors, the prediction models for 1\u2010, 3\u2010, and 5\u2010year periods demonstrated good discrimination, with AUC values of 0.70\u20130.76. Our HTN scoring system for patients with type 2 DM, which involves innovative predictors of glycemic and BP variabilities, has good classification accuracy and identifies risk factors available in clinical settings for prevention of the progression to new\u2010onset HTN.<\/jats:p>","DOI":"10.1111\/jch.14322","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T14:28:53Z","timestamp":1626100133000},"page":"1570-1580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A risk scoring system to predict the risk of new\u2010onset hypertension among patients with type 2 diabetes"],"prefix":"10.1111","volume":"23","author":[{"given":"Cheng\u2010Chieh","family":"Lin","sequence":"first","affiliation":[{"name":"School of Medicine College of Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Family Medicine China Medical University Hospital  Taichung 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