{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:59:32Z","timestamp":1772254772251,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study sought to investigate whether the relation between increased blood pressure (BP) variability and increased arterial stiffness confers a risk for cardiovascular disease (CVD) events. We analyzed 2648 patients from a practitioner\u2010based population (mean\u00a0\u00b1\u00a0SD age 64.9\u00a0\u00b1\u00a011.4 years: 75.8% taking antihypertensive medication) with at least one cardiovascular risk factor who underwent home BP monitoring in the Japan Morning Surge\u2010Home Blood Pressure Study. The standard deviation (SD<jats:sub>SBP<\/jats:sub>), coefficient of variation (CV<jats:sub>SBP<\/jats:sub>), and average real variability (ARV<jats:sub>SBP<\/jats:sub>) were assessed as indexes of day\u2010by\u2010day home systolic BP (SBP) variability. The authors assessed arterial stiffness by brachial\u2010ankle pulse wave velocity (baPWV) and divided patients into lower (&lt;\u00a01800\u00a0cm\/s, n\u00a0=\u00a01837) and higher (\u22651800\u00a0cm\/s, n\u00a0=\u00a0811) baPWV groups. During a mean follow\u2010up of 4.4 years, 95 cardiovascular events occurred (8.1 per 1000 person\u2010years). In Cox proportional hazard models adjusted for traditional cardiovascular risk factors including average home SBP, the highest quartiles of SD<jats:sub>SBP<\/jats:sub> (hazard ratio [HR], 2.30; 95% confidence interval [CI], 1.23\u20104.32), CV<jats:sub>SBP<\/jats:sub> (HR, 2.89; 95%CI, 1.59\u20105.26) and ARV<jats:sub>SBP<\/jats:sub> (HR, 2.55; 95%CI, 1.37\u20104.75) were predictive of CVD events compared to the other quartiles in the higher baPWV group. Moreover, 1SD increases in SD<jats:sub>SBP<\/jats:sub> (HR, 1.44; 95%CI, 1.13\u20101.82), CV<jats:sub>SBP<\/jats:sub> (HR, 1.49; 95%CI, 1.16\u20101.90) and ARV<jats:sub>SBP<\/jats:sub> (HR, 1.37; 95%CI, 1.09\u20101.73) were also predictive of CVD events. These associations remained even after N\u2010terminal pro\u2010brain natriuretic peptide was added to the models. However, these associations were not observed in the lower baPWV group. We conclude that arterial stiffness contributes to the association between home BP variability and CVD incidence.<\/jats:p>","DOI":"10.1111\/jch.14327","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T21:21:54Z","timestamp":1626816114000},"page":"1529-1537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of home blood pressure variability on cardiovascular outcome in patients with arterial stiffness: Results of the J\u2010HOP study"],"prefix":"10.1111","volume":"23","author":[{"given":"Yusuke","family":"Ishiyama","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University  Tochigi 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