{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:05:04Z","timestamp":1760123104643,"version":"3.40.5"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since the COVID\u201019 pandemic, physicians concerned about the potential adverse effects of angiotensin converting enzyme inhibitors (ACEIs)\/angiotensin receptor blockers (ARBs). To explore the relationship between ACEIs\/ARBs and the risk of mortality and other clinical outcomes in COVID\u201019 patients, the authors conducted a systemic review and meta\u2010analysis. An electronic search was performed from inception to November 12, 2020 in PubMed, Medline, EMBASE, ClinicalTrials, TRIP, the Cochrane Library, CNKI, Wanfang, and CBM database. Risk of bias was assessed using the Risk Of Bias In Non\u2010randomized Studies of Interventions tool. The primary outcome was in\u2010hospital all\u2010cause mortality. Secondary outcomes included all\u2010cause mortality measured at 30\u2010day or longer term, mechanical ventilation, length of hospital stay, readmission, and cardiac adverse events. A total of 28 studies with 73\u202f465 patients was included. Twenty\u2010two studies with 19\u202f871 patients reported the incidence of all\u2010cause mortality. Results showed no association between using ACEIs\/ARBs and risk of mortality crude odds ratio \uff08OR\uff09 of 1.02, 95% CI 0.71\u20131.46,<jats:italic>p\u00a0<\/jats:italic>=\u00a0.90,<jats:italic>I<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a088%, adjusted OR in 6260 patients of 0.96, 95% CI 0.77\u20131.18,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.68,<jats:italic>I<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a00%. While six studies with 10\u202f030 patients reported a lower risk of mortality in ACEIs\/ARBs group hazard ratio (HR) of 0.53, 95% CI 0.34\u20130.84,<jats:italic>p\u00a0<\/jats:italic>=\u00a0.007,<jats:italic>I<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a068%. Similar association (for HR) was found in hypertension subgroup. There was no significant association for the secondary outcomes. Based on the available data, we concluded that ACEIs\/ARBs is not associated with the risk of in\u2010hospital all\u2010cause mortality in COVID\u201019 patients, but may be associated with a decreased risk of 30\u2010day all\u2010cause mortality. Patients with hypertension may benefit from using ACEIs\/ARBs.<\/jats:p>","DOI":"10.1111\/jch.14329","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T20:24:04Z","timestamp":1627503844000},"page":"1651-1663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of angiotensin converting enzyme inhibitors\/angiotensin receptor blockers on the risk of all\u2010cause mortality and other clinical outcomes in patients with confirmed COVID\u201019: A systemic review and meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-6891","authenticated-orcid":false,"given":"Na","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The Key Laboratory of Geriatrics Beijing Institute of Geriatrics Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Systematic Review Solutions Ltd Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Chi","sequence":"additional","affiliation":[{"name":"Systematic Review Solutions Ltd Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitong","family":"Dong","sequence":"additional","affiliation":[{"name":"Systematic Review Solutions Ltd Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xia","sequence":"additional","affiliation":[{"name":"Nottingham China Health Institute The University of Nottingham Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The Key Laboratory of Geriatrics Beijing Institute of Geriatrics Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.16.8801-8811.2003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2179-y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2020.04.013"},{"key":"e_1_2_10_5_1","unstructured":"Cardiology CoHotESo.Position statement of the ESC Council on Hypertension on ACE\u2010inhibitors and angiotensin receptor blockers 2020.https:\/\/www.escardio.org\/Councils\/Council\u2010on\u2010Hypertension\u2010(CHT)\/News\/position\u2010statement\u2010of\u2010the\u2010esc\u2010council\u2010on\u2010hypertension\u2010on\u2010ace\u2010inhibitors\u2010and\u2010ang"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0036933020951926"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-020-00994-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6775"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa624"},{"key":"e_1_2_10_11_1","article-title":"Effects of renin\u2010angiotensin system blockers on the risk and outcomes of severe acute respiratory syndrome coronavirus 2 infection in patients with hypertension","author":"Lee J","year":"2021","journal-title":"Korean J. 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