{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:05:06Z","timestamp":1772784306802,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numerous studies have demonstrated that sympathetic nervous system overactivation during exercise in hypertensive rodents and humans is due, in part, to an exaggerated reflex response known as the exercise pressor reflex. Our prior studies have implicated a key role of mineralocorticoid receptor activation in mediating an augmented exercise pressor reflex in spontaneously hypertensive rats, which is mitigated by blockade with eplerenone. However, the effect of eplerenone on exercise pressor reflex has not been assessed in human hypertension. Accordingly, the authors performed a randomized crossover study to compare the effects of eplerenone to another antihypertensive drug from a different class amlodipine on sympathetic nerve activity (SNA) in 14 patients with uncomplicated hypertension. The authors found that amlodipine unexpectedly augmented the increase in SNA during the second minute of isometric handgrip, which persisted into the post\u2010exercise circulatory arrest period (\u2206 SNA, from rest of 15\u00a0\u00b1\u00a02\u00a0vs. 9\u00a0\u00b1\u00a02\u00a0vs. 10\u00a0\u00b1\u00a02 bursts\/min, amlodipine vs. baseline vs. eplerenone, respectively, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), suggesting an exaggerated muscle metaboreflex function. Eplerenone did not alter sympathetic responses to exercise or post\u2010exercise circulatory arrest in the same hypertensive individuals. In conclusions, our studies provide the first direct evidence for a potentially unfavorable potentiation of muscle metaboreflex by amlodipine during isometric handgrip exercise in hypertensive patients whereas eplerenone has no significant effect. Our study may have clinical implications in terms of selection of antihypertensive agents that have the least detrimental effects on sympathetic neural responses to isometric exercise.<\/jats:p>","DOI":"10.1111\/jch.14333","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T15:45:13Z","timestamp":1629906313000},"page":"1706-1714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential effects of eplerenone versus amlodipine on muscle metaboreflex function in hypertensive humans"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-8089","authenticated-orcid":false,"given":"Poghni A.","family":"Peri\u2010Okonny","sequence":"first","affiliation":[{"name":"Hypertension Section University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Velasco","sequence":"additional","affiliation":[{"name":"Hypertension Section University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza","family":"Lodhi","sequence":"additional","affiliation":[{"name":"Hypertension Section University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Hypertension Section University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie","family":"Arbique","sequence":"additional","affiliation":[{"name":"Hypertension Section University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverley","family":"Adams\u2010Huet","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Cell Biology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jere H.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Cardiology Division University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Health Care Sciences University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Health Care Sciences University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanpen","family":"Vongpatanasin","sequence":"additional","affiliation":[{"name":"Hypertension Section University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Cardiology Division University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92526-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(86)90221-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.121558"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01145.2010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01020.2006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01365.2007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.203026"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00556.2010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.106"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00155.2017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.5.1201"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05810"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.2.671"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00237.2016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.3.461"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000067463.13172.EA"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000066"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000270"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-002-0059-1"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113730"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.032367"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00601.2012"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.4.574"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00464.2014"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900053"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-199612030-00003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(01)00285-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11311060005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0983-12.2012"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000244092.95152.86"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-005-0011-5"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2660"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.194787"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.103580"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0b013e318293645f"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000115224.88514.3A"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004473"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-015-0593-6"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(96)00303-2"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000091371.53502.D3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198409273111303"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.14333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T05:30:49Z","timestamp":1697088649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/jch.14333"],"URL":"https:\/\/doi.org\/10.1111\/jch.14333","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,25]]},"assertion":[{"value":"2021-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}