{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:43:36Z","timestamp":1791639816617,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974347"],"award-info":[{"award-number":["81974347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension was one common comorbidity of knee osteoarthritis (KOA), but the effect of different types of antihypertensive drugs on pain and joint space width (JSW) was unclear and not compared. Four hundred ninety KOA patients using one of the beta\u2010blockers, ACE inhibitors, angiotensin receptor blockers, Calcium channel blockers (CCBs), or thiazide diuretics were followed for four years. The blood pressure, cumulative knee replacement rate, Womac pain, and JSW were compared among groups. All data were from the Osteoarthritis Initiative project. The CCBs group has the highest systolic blood pressure, replacement rate, and pain score at most visit timepoints. At baseline, the CCBs group was with significantly higher pain score than the beta\u2010blockers group (3.3 vs 1.3, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), the angiotensin receptor blockers group (3.3 vs 1.4, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), and the thiazide diuretics group (3.3 vs 1.6, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in male; the CCBs group was with significantly higher pain score than the beta\u2010blockers group (3.8 vs 2.0, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), and the angiotensin receptor blockers group (3.8 vs 2.2, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) in female. The results of females at 36 months were similar to the baseline. Among the common antihypertensive drugs, CCBs were associated with high replacement rates, high pain scores, and less JSW in KOA patients.<\/jats:p>","DOI":"10.1111\/jch.14362","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T04:56:17Z","timestamp":1634792177000},"page":"2009-2015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effects of different antihypertensive drugs on pain and joint space width of knee osteoarthritis \u2013 A comparative study with data from Osteoarthritis Initiative"],"prefix":"10.1111","volume":"23","author":[{"given":"Mingyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuangang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-0565","authenticated-orcid":false,"given":"Bin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9"},{"issue":"6","key":"e_1_2_11_3_1","first-page":"1118","article-title":"Association between metabolic factors and knee osteoarthritis in women: the Chingford Study","volume":"22","author":"Hart DJ","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.07.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100569"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007584"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01965"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.11.019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002416"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.November.13.2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60243-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.106930"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23091"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.08.008"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105796"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X16664323"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598897"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1572"},{"issue":"3","key":"e_1_2_11_19_1","first-page":"e372","article-title":"Interaction between antihypertensives and NSAIDs in primary care: a controlled trial","volume":"15","author":"Pavlicevi\u0107 I","year":"2008","journal-title":"Can J Clin Pharmacol"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.12.003"},{"issue":"11","key":"e_1_2_11_21_1","first-page":"E717","article-title":"Interactions between ibuprofen and antihypertensive drugs: incidence and clinical relevance in dental practice","volume":"13","author":"Salort\u2010Llorca C","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001235"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.02.028"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000177507"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-12-93"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199812010-00003"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/31.3.217"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.12.1849"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90276-7"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18082"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/57.1.55"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201020666190506124548"},{"issue":"3","key":"e_1_2_11_33_1","first-page":"817","article-title":"Prohypertensive effects of non\u2010steroidal anti\u2010inflammatory drugs are mostly due to vasoconstriction","volume":"35","author":"Pavlicevi\u0107 I","year":"2011","journal-title":"Coll Antropol"},{"issue":"1","key":"e_1_2_11_34_1","first-page":"R70","article-title":"Diverse effects of calcium channel blockers on skeletal muscle glucose transport","volume":"263","author":"Cartee GD","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key039"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.09.004"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198400282-00002"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06933.2001"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab234"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.14362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T05:32:51Z","timestamp":1697088771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,17]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jch.14362"],"URL":"https:\/\/doi.org\/10.1111\/jch.14362","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,17]]},"assertion":[{"value":"2021-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}