{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:50:23Z","timestamp":1790297423668,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here, we report a case of unilateral adrenal aldosterone and cortisol co\u2010secreting adenoma. A 34\u2010year\u2010old man with a history of severe hypertension for one year was detected hypokalemia (2.42\u00a0mmol\/L lowest) and unilateral adrenal mass in a size of 71\u00a0mm*63\u00a0mm. Measurements of plasma aldosterone concentration and plasma renin activity showed marked increases. Primary aldosteronism was diagnosed. To exclude adrenal malignancy, the function of zona fasciculate was evaluated, and 24\u2010h urine free cortisol was found abnormal in a testing. Further examinations revealed that circadian rhythm of serum cortisol disappeared and 2\u00a0mg\u2010dexamethasone suppression test was positive. The final diagnosis was secondary hypertension, primary aldosteronism and subclinical Cushing's syndrome. After unilateral adrenalectomy, his blood pressure was normalized and biochemical parameters in the normal range. In conclusion, in patients with a large aldosterone\u2010producing adenoma, the function of zona fasciculate might have to be evaluated for the identification of aldosterone and cortisol co\u2010secreting neoplasms.<\/jats:p>","DOI":"10.1111\/jch.14374","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T04:54:54Z","timestamp":1634792094000},"page":"1987-1991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypertension with unilateral adrenal aldosterone and cortisol cosecreting adenoma: A case report"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-2240","authenticated-orcid":false,"given":"Zhe","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Hypertension Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hypertension Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Urology Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Xiu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Li","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Hypertension Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hypertension Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90883-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834937f3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-020-2353-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-019-0395-y"},{"key":"e_1_2_7_6_1","article-title":"A rare case of subclinical primary aldosteronism and subclinical Cushing's syndrome without cardiovascular complications","volume":"41","author":"Kitajima N","year":"2016","journal-title":"Tokai J Exp Clin 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