{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:50:11Z","timestamp":1770749411690,"version":"3.50.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to investigate the association between serum uric acid (SUA) level and development of hypertension as well as the interaction effect of chronic kidney disease (CKD) on this relationship in the general Japanese population. We included 7895 participants aged \u226530 years from the ISSA\u2010CKD study, a population\u2010based retrospective cohort study that used annual health check\u2010up data of residents from Iki Island, Japan. After the exclusion of 1881 with l\u00a0&lt;\u00a01\u2010year follow\u2010up, 2812 with hypertension at baseline, and 165 with missing information on SUA, a total of 3037 participants were enrolled in this analysis. Participants were divided into four groups according to the quartiles of SUA level at baseline, and multivariable\u2010adjusted hazard ratios for new\u2010onset hypertension were calculated. Stratified analyses were performed for each subgroup (defined by sex, age, alcohol intake, and CKD) to assess the interaction effects. During a mean follow\u2010up period of 4.4 years, 943 participants developed hypertension. The first quartile group was set as the reference group, and the multivariable\u2010adjusted hazard ratios (95% confidence interval) for new\u2010onset hypertension were 1.11 (0.90\u20131.36) in the second quartile, 1.25 (1.02\u20131.54) in the third quartile, and 1.35 (1.07\u20131.70) in the fourth quartile compared with those in the reference group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.007 for trend). The stratified analyses showed that the association between SUA and hypertension was significantly stronger in participants with CKD than in those without CKD (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035 for interaction). SUA level is an independent risk factor for new\u2010onset hypertension. This tendency was significantly stronger in participants with CKD.<\/jats:p>","DOI":"10.1111\/jch.14390","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T04:56:18Z","timestamp":1637556978000},"page":"2071-2077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of chronic kidney disease on the association between hyperuricemia and new\u2010onset hypertension in the general Japanese population: ISSA\u2010CKD study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-9452","authenticated-orcid":false,"given":"Miki","family":"Kawazoe","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Funakoshi","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-8458","authenticated-orcid":false,"given":"Chikara","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Faculty of Medicine Fukuoka University  Fukuoka Japan"},{"name":"Department of Respiratory Medicine Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health Faculty of Medicine Fukuoka University  Fukuoka 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