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The aim of this study was to determine whether RMR is reduced in hypertensive patients treated with angiotensin\u2010converting enzyme inhibitors (ACEI) and blockers (ARB). The RMR was determined by indirect calorimetry in 174 volunteers; 93 (46.5 %) were hypertensive, of which 16 men and 13 women were treated with ACEI\/ARB, while 30 men and 19 women with untreated hypertension served as a control group. Treated and untreated hypertensives had similar age, BMI, physical activity, and cardiorespiratory fitness. The RMR normalized to the lean body mass (LBM) was 15% higher in the untreated than ACEI\/ARB\u2010treated hypertensive women (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). After accounting for LBM, whole\u2010body fat mass, age, the double product (heart rate x systolic blood pressure), and the distance walked per day, the RMR was 2.9% lower in the patients taking ACEI\/ARB (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.26, treatment x sex interaction <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). LBM, age, and the double product explained 78% of the variability in RMR (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.78, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). In contrast, fat mass, the distance walked per day, and total T4 or TSH did not add predictive power to the model. Compared to men, a greater RMR per kg of LBM was observed in untreated hypertensive overweight and obese women, while this sex difference was not observed in patients treated with ACEI or ARBs. In conclusion, our results indicate that elevated RMR per kg of LBM may be normalized by antagonizing the renin\u2010angiotensin system.<\/jats:p>","DOI":"10.1111\/jch.14392","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T23:10:46Z","timestamp":1638313846000},"page":"2106-2114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of hypertension with angiotensin\u2010converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross\u2010sectional study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-500X","authenticated-orcid":false,"given":"Pablo B.","family":"Pedrianes\u2010Martin","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital Universitario de Gran Canaria Doctor Negr\u00edn  Las Palmas de Gran Canaria Spain"},{"name":"Research Institute of Biomedical and Health Sciences (IUIBS) University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria  Canary Islands Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-2331","authenticated-orcid":false,"given":"Marcos","family":"Martin\u2010Rincon","sequence":"additional","affiliation":[{"name":"Research Institute of Biomedical and Health Sciences (IUIBS) University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria  Canary Islands Spain"},{"name":"Department of Physical Education University of Las Palmas de Gran Canaria  Las Palmas de Gran Canaria Canary Islands Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-397X","authenticated-orcid":false,"given":"David","family":"Morales\u2010Alamo","sequence":"additional","affiliation":[{"name":"Research Institute of Biomedical and Health Sciences (IUIBS) University of Las Palmas de Gran Canaria Las Palmas de Gran 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