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In the current study, a cardiovascular risk assessment model was constructed in a hypertensive population. This prospective cohort study was conducted with cardiovascular examinations in rural northeast China in 2012 and 2013, and followed up to collect cardiovascular events in 2015 and 2018. Data were derived from 4763 hypertensive patients who were free of cardiovascular disease (CVD) at baseline and completed follow\u2010up. After lasso regression was used to screen for risk factors of CVD at baseline, a multivariate Cox regression risk model was established and a nomogram was developed. The model was validated using an independent test set (one third of data not used for model building). Among 4763 patients, 354 (7.43%) had a cardiovascular event during a median follow\u2010up of 4.66 years. Nine risk factors were screened by lasso regression, including sex, age, current smoking, body mass index (BMI), history of transient ischemic attack (TIA), family history of hypertension, family history of stroke,\u00a0physical labor intensity, and high low\u2010density lipoprotein cholesterol (LDL\u2010C). The c\u2010index of the CVD model was 0.707, and that of an updated model with baseline blood pressure was 0.732. In the validated cohort the respective c\u2010indexes were 0.665 and 0.714. An assessment model of CVD risk was established in a hypertensive population which may provide an original prevention strategy for hypertensive populations in rural China, and further reduce the CVD burden.<\/jats:p>","DOI":"10.1111\/jch.14403","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T11:09:14Z","timestamp":1639048154000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Construction of a risk assessment model of cardiovascular disease in a rural Chinese hypertensive population based on lasso\u2010Cox analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Nanxiang","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Cardiology First Hospital of China Medical University  Shenyang 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